Nucleotide-oligomerizing domain-1 (NOD1) receptor activation induces pro-inflammatory responses and autophagy in human alveolar macrophages.
AuthorsJuárez E, Carranza C, Hernández-Sánchez F, Loyola E, Escobedo D, León-Contreras JC, Hernández-Pando R, Torres M, Sada E,
Journal
PubMed ID25253572
'Nucleotide-binding oligomerizing domain-1 (NOD1) is a cytoplasmic receptor involved in recognizing bacterial peptidoglycan fragments that localize to the cytosol. NOD1 activation triggers inflammation, antimicrobial mechanisms and autophagy in both epithelial cells and murine macrophages. NOD1 mediates intracellular pathogen clearance in the lungs of mice; however, little is known about NOD1''s ... More
Activation of autophagy in response to nanosecond pulsed electric field exposure.
AuthorsUllery JC, Tarango M, Roth CC, Ibey BL,
Journal
PubMed ID25660455
Previous work demonstrated significant changes in cellular membranes following exposure of cells to nanosecond pulsed electric fields (nsPEF), including nanoporation and increases in intracellular calcium concentration. While it is known that nsPEF exposure can cause cell death, how cells repair and survive nsPEF-induced cellular damage is not well understood. In ... More
Tools and techniques to measure mitophagy using fluorescence microscopy.
AuthorsDolman NJ, Chambers KM, Mandavilli B, Batchelor RH, Janes MS,
Journal
PubMed ID24121704
Mitophagy is a specialized form of autophagy that removes damaged mitochondria, thereby maintaining efficient cellular metabolism and reducing cellular stress caused by aberrant oxidative bursts. Deficits in mitophagy underlie several diseases, and a substantial body of research has elucidated key steps in the pathways that lead to and execute autophagic ... More
Loperamide Restricts Intracellular Growth of Mycobacterium tuberculosis in Lung Macrophages.
AuthorsJuárez E, Carranza C, Sánchez G, González M, Chávez J, Sarabia C, Torres M, Sada E
JournalAm J Respir Cell Mol Biol
PubMed ID27468130
'New approaches for improving tuberculosis (TB) control using adjunct host-directed cellular and repurposed drug therapies are needed. Autophagy plays a crucial role in the response to TB, and a variety of autophagy-inducing drugs that are currently available for various medical conditions may serve as an adjunct treatment in pulmonary TB. ... More
Inhibition of endoplasmic reticulum stress-induced autophagy sensitizes melanoma cells to temozolomide treatment.
AuthorsRyabaya O, Prokofieva A, Khochenkov D, Abramov I, Zasedatelev A, Stepanova E
JournalOncol Rep
PubMed ID29749510
'The incidence of malignant melanoma is increasing. The discovery of agents specifically targeting the mutated cascades has provided a good response for patients with oncogenic B-Raf proto-?ncogene, serine/threonine kinase (BRAF). However, numerous studies continue to focus on novel methods of treatment to overcome acquired resistance to novel drugs. Recently, it ... More
Implantable and degradable antioxidant poly(e-caprolactone)-lignin nanofiber membrane for effective osteoarthritis treatment.
AuthorsLiang R, Zhao J, Li B, Cai P, Loh XJ, Xu C, Chen P, Kai D, Zheng L
JournalBiomaterials
PubMed ID31711715
'Osteoarthritis (OA) is one of the most common musculoskeletal disorders worldwide. Oxidative stress initiated by excessive free radicals such as reactive oxygen species (ROS) is a leading cause of cartilage degradation and OA. However, conventional injection or oral intake of antioxidants usually cannot provide effective treatment due to rapid clearance ... More
Phagocytosis of Candida albicans Inhibits Autophagic Flux in Macrophages.
Authors
JournalOxid Med Cell Longev
PubMed ID29887941
Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer's Disease.
Authors
JournalCell Rep
PubMed ID30590039
A broad-spectrum antibiotic, DCAP, reduces uropathogenic Escherichia coli infection and enhances vorinostat anticancer activity by modulating autophagy.
Authors
JournalCell Death Dis
PubMed ID30006504
A family of PIKFYVE inhibitors with therapeutic potential against autophagy-dependent cancer cells disrupt multiple events in lysosome homeostasis.