Analyzing antibody specificity with whole proteome microarrays.
AuthorsMichaud GA, Salcius M, Zhou F, Bangham R, Bonin J, Guo H, Snyder M, Predki PF, Schweitzer BI,
JournalNat Biotechnol
PubMed ID14608365
'Although approximately 10,000 antibodies are available from commercial sources, antibody reagents are still unavailable for most proteins. Furthermore, new applications such as antibody arrays and monoclonal antibody therapeutics have increased the demand for more specific antibodies to reduce cross-reactivity and side effects. An array containing every protein for the relevant ... More
Functional protein microarrays: just how functional are they?
AuthorsMerkel JS, Michaud GA, Salcius M, Schweitzer B, Predki PF,
JournalCurr Opin Biotechnol
PubMed ID16006113
'Arrays of immobilized proteins have been developed for the discovery and characterization of protein functions ranging from molecular recognition to enzymatic activity. The success of these applications is highly dependent upon the maintenance of protein structure and function while in an immobilized state - a largely untested hypothesis. However, the ... More