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Invitrogen

GNAI1/GNAI2 Polyclonal Antibody

Advanced Verification
1 Published Figure
5 References
View all (2) GNAI1/GNAI2 antibodies

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GNAI1/GNAI2 Polyclonal Antibody

Product Details

PA1-1000

Applications
Tested Dilution
Publications

Western Blot (WB)

1 µg/mL
View 3 publications 3 publications

Immunocytochemistry (ICC/IF)

2 µg/mL
-

Immunoprecipitation (IP)

Assay-dependent
View 2 publications 2 publications
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues K(346) N N L K D C G L F(355) of human G Protein alpha Inhibitor 1/2.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2232440

Product Specific Information

PA1-1000 detects G protein alpha inhibitor 1/2 from human, rat, and mouse tissues and cells.

PA1-1000 has been successfully used in Immunoprecipitation and Western blot procedures. By Western blot, this antibody detects an ~38 kDa protein representing G protein alpha inhibitor 1/2 from HeLa cell lysate.

The PA1-1000 immunogen is a synthetic peptide corresponding to residues K(346) N N L K D C G L F(355) of human G Protein alpha Inhibitor 1/2. This sequence is completely conserved in human, rat, guinea pig, hamster, bovine, hydra, octopus, Xenopus, chicken, canine, spiny dogfish, great pond snail, starfish, and American lobster G protein alpha inhibitor 1/2. PA1-1000 immunizing peptide (Cat. # PEP-129) is available for use in neutralization and control procedures.

Target Information

The G protein family of signal transducers includes the alpha, beta, gamma subunits and the effector which are most clearly distinguished by their different alpha chains. The family also includes Gs and Gi, the stimulatory and inhibitory GTP-binding regulators of adenylate cyclase; Go, a protein of unknown function that is abundantly expressed in brain; and transducin 1 and 2, proteins involved in retinal phototransduction. The G proteins possess GTPase activity and are components of a complex membrane signaling system that includes membrane-bound receptors. The system exists to modulate extracellular signals as they are transmitted into the cell.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: adenylate cyclase-inhibiting G alpha protein; G alpha inhibitory type 2 (a); G alpha inhibitory type 2 (b); G protein; Gi1 protein alpha subunit; GNAI2; GTP-binding protein; GTP-binding protein (G-alpha-i2); GTP-binding regulatory protein Gi alpha-2 chain; guanine nucleotide binding protein (G protein), alpha inhibiting 1; guanine nucleotide binding protein (G protein), alpha inhibiting 2; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; guanine nucleotide binding protein, alpha inhibiting 1; guanine nucleotide binding protein, alpha inhibiting 2; Guanine nucleotide-binding protein alpha subunit; guanine nucleotide-binding protein alpha-i subunit; guanine nucleotide-binding protein G(i), alpha-1 subunit; guanine nucleotide-binding protein G(i), alpha-2 subunit; guanine nucleotide-binding regulatory protein alpha-inhibitory subunit; heterotrimeric guanine nucleotide-binding protein 1B; heterotrimeric guanine nucleotide-binding protein 1C; inhibitory G protein of adenylate cyclase, alpha chain; sGi2; unnamed protein product

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Gene Aliases: BPGTPB; Galphai2; Gi; Gia; Gialpha1; GIP; Gnai-1; Gnai-2; GNAI2B; H_LUCA15.1; H_LUCA16.1; HG1B; HG1C; NEDHISB

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UniProt ID: (Human) P63096, (Human) P04899, (Mouse) B2RSH2, (Rat) P10824, (Rat) P04897, (Mouse) P08752

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Entrez Gene ID: (Human) 2770, (Human) 2771, (Mouse) 14677, (Rat) 25686, (Rat) 81664, (Mouse) 14678

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Function(s)
magnesium ion binding G-protein coupled receptor binding GTPase activity obsolete small monomeric GTPase activity protein binding GTP binding adenylate cyclase inhibitor activity guanyl nucleotide binding GDP binding G-protein beta/gamma-subunit complex binding D2 dopamine receptor binding G-protein coupled serotonin receptor binding adenylate cyclase regulator activity GTPase activating protein binding
Process(es)
signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting dopamine receptor signaling pathway adenylate cyclase-inhibiting serotonin receptor signaling pathway neuropeptide signaling pathway response to prostaglandin E mast cell degranulation positive regulation of cholesterol biosynthetic process negative regulation of synaptic transmission cell division regulation of mitotic spindle organization chemokine-mediated signaling pathway T cell migration neurotransmitter receptor localization to postsynaptic specialization membrane regulation of eating behavior cellular response to forskolin positive regulation of protein localization to cell cortex angiogenesis adenosine receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity gamma-aminobutyric acid signaling pathway response to nutrient positive regulation of cell proliferation positive regulation of cell migration positive regulation of superoxide anion generation positive regulation of urine volume negative regulation of calcium ion-dependent exocytosis modulation of synaptic transmission regulation of calcium ion transport positive regulation of ERK1 and ERK2 cascade negative regulation of adrenergic receptor signaling pathway positive regulation of vascular smooth muscle cell proliferation positive regulation of neural precursor cell proliferation negative regulation of apoptotic signaling pathway G-protein coupled acetylcholine receptor signaling pathway G-protein coupled glutamate receptor signaling pathway cell proliferation positive regulation of NAD(P)H oxidase activity establishment of mitotic spindle orientation regulation of G-protein coupled receptor protein signaling pathway response to peptide hormone positive regulation of relaxation of smooth muscle
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