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Invitrogen
PP2A alpha Polyclonal Antibody
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FIGURE: 1 / 4
PP2A alpha Antibody (PA1-12393) in ICC/IF
Immunofluorescence analysis of PP2A alpha was performed using 70% confluent log phase PC-3 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with PP2A alpha Polyclonal Antibody (Product # PA1-12393) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsiu... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-12393
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
0.08% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. The PP2A family comprises subfamily members PP2A alpha and PP2A beta. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B55-GAMMA; IMYPNO; IMYPNO1; Methyl-PPP2CA; MGC33570; PP2A alpha; PP2A C terminal; PP2A L9; PP2A Leucine 9; PP2A-alpha; PR52; PR55G; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isoform; protein phosphatase 2a, catalytic subunit, alpha isoform; protein phosphatase type 2A catalytic subunit; protein phosphatase-2A-alpha; Replication protein C; RP-C; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; unnamed protein product
Gene Aliases: PP2A; Pp2a1; PPP2CA; R75353
UniProt ID: (Bovine) P67774, (Mouse) P63330, (Rat) P63331
Entrez Gene ID: (Bovine) 282320, (Mouse) 19052, (Rat) 24672
protein serine/threonine phosphatase activity
protein C-terminus binding
metal ion binding
protein heterodimerization activity
GABA receptor binding
phosphoprotein phosphatase activity
protein binding
hydrolase activity
enzyme binding
protein kinase binding
protein phosphatase binding
protein domain specific binding
protein complex binding
protein kinase B binding
ion channel binding
protein dimerization activity
tau protein binding
protein phosphatase 2A binding
protein antigen binding
protein phosphatase
mesoderm development
negative regulation of epithelial to mesenchymal transition
peptidyl-threonine dephosphorylation
meiotic cell cycle
positive regulation of protein serine/threonine kinase activity
negative regulation of transcription from RNA polymerase II promoter
regulation of protein phosphorylation
negative regulation of protein phosphorylation
protein dephosphorylation
regulation of receptor activity
regulation of protein autophosphorylation
positive regulation of protein phosphatase type 2A activity
positive regulation of protein dephosphorylation
regulation of protein catabolic process
negative regulation of transcription factor import into nucleus
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cell cycle
protein heterotrimerization
cellular response to glucose stimulus
negative regulation of calcium ion transmembrane transporter activity
cardiac ventricle development
heart development
cellular response to insulin stimulus
cellular response to calcium ion
cellular response to cytokine stimulus
cellular response to ethanol
cellular response to follicle-stimulating hormone stimulus
cellular response to steroid hormone stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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