Search
Invitrogen
OPA1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA1-16991
应用
建议稀释比
已发表文章
产品规格
种属反应
Chicken,
Human,
Mouse,
Pig,
Rat,
Zebrafish
已发表种属
Goat,
Human,
Mouse,
Pig
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide made to an internal region within residues 500-600 of human OPA1.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody shares 100% sequence homology with primate, 94% with zebrafish.
Suggested positive control: human brain protein.
靶标信息
OPA1 is a dynamin-related GTPase that is critical for the maintenance of mitochondrial morphology and mtDNA. The most commonly associated phenotype with OPA1 mutations is heterozygous optic atrophy, a heterozygous dominant trait that causes reduced visual clarity and sometimes blindness. The disease usually begins in childhood and increases in severity throughout the life of affected individuals. Usually, this phenotype is attributed to the degeneration of optic nerve fibers. Interestingly, the same type of nerve degeneration seems to be partially causative of certain schizophrenia characteristics. OPA1 dysfunction also seems to be implicated in this case; mitochondrial networks associated with critical nerves seem to link schizophrenia and OPA1. The dysfunction is associated with issues with apoptosis and normal cellular metabolic regulation, all regulated through OPA1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: dynamin-like 120 kDa protein, mitochondrial; Dynamin-like GTPase OPA1, mitochondrial; Large GTP-binding protein; LargeG; mitochondrial OPA1; opa1 {ECO:0000312|EMBL:AAI11072.1}; optic atrophy 1 (autosomal dominant); optic atrophy 1 homolog; optic atrophy 1-like protein; Optic atrophy protein 1; Optic atrophy protein 1 homolog; RN protein
基因别名: 1200011N24Rik; AI225888; AI847218; fk62d06; KIAA0567; lilr3; mKIAA0567; OPA1; RCJMB04_1m16; wu:fb77a10; wu:fk62d06; zgc:92092
UniProt ID: (Chicken) Q5F499, (Rat) Q2TA68, (Mouse) P58281, (Zebrafish) Q5U3A7
Entrez Gene ID: (Pig) 100522705, (Chicken) 424900, (Rat) 171116, (Mouse) 74143, (Zebrafish) 492332
mitochondrial fission
dynamin polymerization involved in mitochondrial fission
apoptotic process
mitochondrial fusion
GTP metabolic process
organelle fission
membrane fusion
membrane tubulation
mitochondrial genome maintenance
neural tube closure
mitochondrion organization
inner mitochondrial membrane organization
aging
visual perception
metabolic process
positive regulation of mitochondrial fusion
positive regulation of neuron maturation
negative regulation of release of cytochrome c from mitochondria
cellular senescence
positive regulation of dendrite development
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of intrinsic apoptotic signaling pathway
response to stimulus
chordate embryonic development
ventricular cardiac muscle cell development
mitochondrion morphogenesis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
