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Invitrogen
Collagen II Polyclonal Antibody
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Collagen II Antibody (PA1-26206) in IHC (P)
Immunohistochemistry (Paraffin) analysis of Collagen II was performed in FFPE human bronchiolar cartilage tissue using Collagen II Polyclonal Antibody (Product # PA1-26206) at a dilution of 1:400 for 45 min at RT. Slides were steamed in 0.01 M sodium citrate buffer, pH 6.0 at 99-100°C - 20 minutes for antigen retrieval.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA1-26206
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Human,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Collagen Type II from human knee cartilage and bovine nasal cartilage.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.15 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 8.0
内含物
0.01% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: chondrocyte tissue.
PA1-26206 is expected to cross react with most mammals due to sequence homology. This antibody shows negligable cross reactivity with the Collagens 1, 3, 4, 5, and 6.
靶标信息
COL2A1 is the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Alpha-1 type II collagen; CGA; Collagen 2; Collagen alpha-1(II) chain; collagen type II (Col2A1) gene, enhancer region; collagen, type II, alpha 1; MGC131516; pro-alpha 1(II); Procollagen II alpha 1; procollagen, type II, alpha 1; unnamed protein product
基因别名: CB11; CG2A1A; COL2A1; COLLII
UniProt ID: (Bovine) P02459, (Rat) P05539
Entrez Gene ID: (Bovine) 407142, (Rat) 25412
cartilage condensation
tissue homeostasis
endochondral ossification
chondrocyte differentiation
heart morphogenesis
proteoglycan metabolic process
central nervous system development
visual perception
sensory perception of sound
regulation of gene expression
inner ear morphogenesis
palate development
limb bud formation
embryonic skeletal joint morphogenesis
cartilage development involved in endochondral bone morphogenesis
otic vesicle development
cellular response to BMP stimulus
anterior head development
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
skeletal system development
growth plate cartilage development
response to mechanical stimulus
response to X-ray
collagen fibril organization
notochord development
limb morphogenesis
skeletal system morphogenesis
inner ear development
cartilage development
bone development
cellular response to mechanical stimulus
cellular response to retinoic acid
cellular response to vitamin E
cellular response to nicotine
cellular response to tumor necrosis factor
cellular response to parathyroid hormone stimulus
cellular response to peptide hormone stimulus
response to fibroblast growth factor
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