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Invitrogen
GRB2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA1-31495
产品规格
种属反应
Human,
Mouse,
Pig,
Rat
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence C-PRNYVTPVNRNV, from the C Terminus.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
50 µg
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: The peptide used to generate this antibody is available for purchase (GTX22234-PEP)..
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
GRB 2 protein contains one SH2 domain flanked on both sides by an SH3 domain. In response to EGF, GRB 2 binds, through its SH3 domains, to the guanine nucleotide exchange factor, Sos. The GRB 2-Sos complex then binds the EGF receptor. These interactions play a critical role in the activation of the p21 ras signaling pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Adapter protein GRB2; ASH protein; Growth factor receptor-bound protein 2; OTTHUMP00000166097; OTTHUMP00000166098; Protein Ash; SH2/SH3 adapter GRB2
基因别名: AA408164; ASH; GRB2
UniProt ID: (Mouse) Q60631, (Rat) P62994
Entrez Gene ID: (Pig) 100192436, (Mouse) 14784, (Rat) 81504
phosphotyrosine binding
SH3/SH2 adaptor activity
epidermal growth factor receptor binding
neurotrophin TRKA receptor binding
protein binding
SH3 domain binding
protein kinase binding
protein phosphatase binding
protein domain specific binding
identical protein binding
insulin receptor substrate binding
poly(A) RNA binding
ephrin receptor binding
phosphoprotein binding
Ras protein signal transduction
aging
insulin receptor signaling pathway
fibroblast growth factor receptor signaling pathway
positive regulation of signal transduction
cell differentiation
positive regulation of actin filament polymerization
receptor internalization
signal transduction in response to DNA damage
regulation of MAPK cascade
anatomical structure formation involved in morphogenesis
protein heterooligomerization
branching involved in labyrinthine layer morphogenesis
cellular response to ionizing radiation
positive regulation of reactive oxygen species metabolic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
