Search
Invitrogen
FOXA2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-31936
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-GVYSRPIMNSS, from the C Terminus.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: The peptide used to generate this antibody is available for purchase (GTX25074-PEP)..
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin. They also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. FOXA2 has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FKHL20; Forkhead box protein A2; hepatocyte nuclear factor 3, beta; Hepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B; MGC19807; RONU; TCF-3B; Transcription factor 3B; WHN
Gene Aliases: FOXA2; HNF3B; Tcf-3b; TCF3B
UniProt ID: (Rat) P32182
Entrez Gene ID: (Rat) 25099
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
transcription factor binding
kinase binding
protein domain specific binding
sequence-specific DNA binding
transcription regulatory region DNA binding
SMAD binding
winged helix/forkhead transcription factor
positive regulation of transcription from RNA polymerase II promoter by glucose
negative regulation of transcription from RNA polymerase II promoter by glucose
in utero embryonic development
ectoderm formation
cell fate specification
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
pattern specification process
adult locomotory behavior
anatomical structure morphogenesis
anterior/posterior pattern specification
dorsal/ventral pattern formation
regulation of gene expression
negative regulation of epithelial to mesenchymal transition
chromatin modification
regulation of lipid metabolic process
regulation of steroid metabolic process
cell differentiation in hindbrain
dorsal/ventral neural tube patterning
signal transduction involved in regulation of gene expression
regulation of blood coagulation
lung development
endocrine pancreas development
somite rostral/caudal axis specification
response to insulin
negative regulation of glucokinase activity
positive regulation of embryonic development
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of smoothened signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase III promoter
cell development
anatomical structure formation involved in morphogenesis
neuron fate specification
epithelial tube branching involved in lung morphogenesis
lung epithelial cell differentiation
regulation of insulin secretion involved in cellular response to glucose stimulus
connective tissue development
dopaminergic neuron differentiation
primitive streak formation
positive regulation of gastrulation
negative regulation of detection of glucose
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support