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Invitrogen
p70 S6 Kinase Polyclonal Antibody
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产品信息
PA1-32330
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to a portion of the C-terminus of human ribosomal protein S6 kinase, 70 kDa. (LocusLink ID 6197).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
保存条件
4°C, do not freeze
运输条件
Wet ice
产品详细信息
PA1-32330 detects p70 S6 from rat samples. PA1-32330 is expected to react with human and mouse samples due to sequence homology.
PA1-32330 has been successfully used in Western blot applications.
The PA1-32330 immunogen is a synthetic peptide corresponding to a portion of the C-terminus of human ribosomal protein S6 kinase, 70 kDa. (LocusLink ID 6197).
靶标信息
RPS6KB1 (p70S6K) is a serine/threonine kinase with 2 non-identical kinase catalytic domains which phosphorylates several residues of the S6 ribosomal protein. p70 S6 kinase is predominantly localized in the cytoplasm, and is essential in growth factors regulated cell proliferation, pathways involving cell motility, such as metastases, the immune response, and tissue repair. p70 S6 kinase acts downstream of phosphoinositide (PI) 3-kinase, and its main physiological target is the S6 ribosomal protein, which is involved in upregulation of protein synthesis. The kinase activity of p70 S6 kinase leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding p70 S6 kinase and overexpression are seen in some breast cancer cell lines.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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