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Invitrogen
Phospho-MEK1 (Thr292) Polyclonal Antibody
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Phospho-MEK1 (Thr292) Antibody (PA1-4630) in WB
Western blot of recombinant wild type MEK 1 (WT) and mutant MEK1 (Mut). Specific immunolabeling of a band at ~45 kDa corresponding to Phospho-MEK1 (Thr292) polyclonal antibody (Product # PA1-4630), which is shown in the second lane where MAP kinase was coexpressed.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA1-4630
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr292 of human MAP2K1 conjugated to KLH
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.25 mg/mL
规格
25 µg
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with bovine, canine, mouse, non-human primate and rat based on 100% sequence homology.
This antibody is specific for the ~45 kDa MEK 1 protein phosphorylated at Thr292 in Western blots of human brain extracts.
靶标信息
MAP2K1 (MEK1) kinase is a dual-specificity protein kinase that functions in mitogen-activated protein kinase (MAPK) cascades, controlling cell growth and differentiation. MAP2K1 is activated by a wide variety of growth factors and cytokines and also by membrane-dependent depolarization and calcium influx. Mek1 is activated by phosphorylation of serine 218 and 222 residues by Raf1. It is known to be involved in the signaling during stress activate response, apoptosis and proliferative induction by cytokines. Mutations in the gene can lead to cardiofaciocutaneous syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dual specificity mitogen-activated protein kinase kinase 1; EC 2.7.12.2; ERK activator kinase 1; kinase MEK1; MAP kinase kinase 1; MAPK/ERK kinase 1; MAPKK 1; MEK 1; MEK2; mitogen activated protein kinase kinase 1; MKK (Thr292); MKK (Thr386); MKK2; MP2K1; PRKMK2; protein kinase, mitogen activated, kinase 1, p45
基因别名: MAP2K1; MAPKK1; MEK1; MEKK1; PRKMK1
UniProt ID: (Mouse) P31938
Entrez Gene ID: (Mouse) 26395
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
receptor signaling protein tyrosine phosphatase activity
protein binding
ATP binding
protein C-terminus binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Ras GTPase binding
protein kinase binding
mitogen-activated protein kinase kinase kinase binding
protein serine/threonine kinase activator activity
protein N-terminus binding
non-receptor serine/threonine protein kinase
MAPK cascade
activation of MAPK activity
regulation of protein phosphorylation
regulation of vascular smooth muscle contraction
protein phosphorylation
response to oxidative stress
cell cycle arrest
mitotic nuclear division
cell proliferation
negative regulation of cell proliferation
positive regulation of gene expression
phosphorylation
neuron differentiation
keratinocyte differentiation
positive regulation of cell migration
melanosome transport
regulation of stress-activated MAPK cascade
positive regulation of transcription elongation from RNA polymerase II promoter
negative regulation of homotypic cell-cell adhesion
peptidyl-tyrosine dephosphorylation
positive regulation of GTPase activity
positive regulation of cell differentiation
positive regulation of Ras protein signal transduction
vesicle transport along microtubule
Golgi inheritance
response to axon injury
regulation of axon regeneration
neuron projection morphogenesis
cell motility
positive regulation of axonogenesis
protein heterooligomerization
response to glucocorticoid
lung morphogenesis
trachea formation
epithelial cell proliferation involved in lung morphogenesis
placenta blood vessel development
labyrinthine layer development
ERK1 and ERK2 cascade
positive regulation of protein serine/threonine kinase activity
regulation of Golgi inheritance
cellular senescence
mitophagy in response to mitochondrial depolarization
regulation of early endosome to late endosome transport
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