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Invitrogen
Phospho-NMDAR2A/NMDAR2B (Tyr1252) Polyclonal Antibody
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Phospho-NMDAR2A/NMDAR2B (Tyr1252) Antibody (PA1-4632) in WB
Western blot of rat hippocampal lysate showing specific immunolabeling of the ~180 kDa NR2B subunit of the NMDAR (Lane 1). The phosphospecificty of this labeling is shown in Lane 2 (lambda phosphatase). The blot is identical to the control except that it was incubated in lambda-Ptase (1200 units for 30 min) before being exposed to the Anti Phospho Tyr1252 NMDA NR2B subunit. The immunolabeling of NR2B is com... View More
产品信息
PA1-4632
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phospho-peptide corresponding to amino acid residues surrounding Tyr1252 of rat GRIN2B conjugated to KLH
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
This antibody is predicted to react with bovine, canine, chicken, human, mouse, non-human primate and zebrafish based on 100% sequence homology.
This antibody is specific for ~180 kDa NMDAR NR2B subunit protein phosphorylated at Tyr1252. Immunolabeling is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide. Immunolabeling of the NMDAR NR2B subunit band is blocked by lambda-phosphatase treatment.
靶标信息
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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