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Phospho-PLK1 (Ser482, Ser486, Ser490) Polyclonal Antibody
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Phospho-PLK1 (Ser482, Ser486, Ser490) Antibody (PA1-4637) in WB
Western blot of PLK1 in rat hippocampal membrane lysate showing specific immunolabeling of a band at ~120 kDa corresponding to Phospho-PLK1 (Ser482, Ser486, Ser490) polyclonal antibody (Product # PA1-4637) in the first lane (-). Phosphospecificity is shown in the second lane (+) where the immunolabeling is completely eliminated by blot treatment with lambda phosphatase (1,200 units overnight).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA1-4637
产品规格
种属反应
Rat,
Xenopus
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser482/486/490 of Xenopus PLK1 conjugated to KLH
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.25 mg/mL
规格
25 µg
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with rat, mouse, human and zebrafish based on 100% sequence homology.
This antibody is specific for the ~120 kDa PLKK protein phosphorylated at Ser482,486,490 in Western blots of Xenopus lysates.
靶标信息
PLK1 is a serine/threonine kinase that is thought to function in cell mitosis and regarded as a marker of cell proliferation. It has been found to play a critical role in carcinogenesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: PLK 1; PLK-1; Plx1; polo-like kinase; Polo-like kinase 1; polo-like kinase homolog; Serine/threonine-protein kinase PLK1; STPK14
基因别名: Plk; Plk1; plx1; XELAEV_18047692mg
UniProt ID: (Rat) Q62673, (Xenopus) P70032
Entrez Gene ID: (Rat) 25515, (Xenopus) 380481
mitotic sister chromatid segregation
G2/M transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
mitotic cytokinesis
microtubule bundle formation
protein phosphorylation
mitotic nuclear division
mitotic spindle assembly checkpoint
regulation of mitotic cell cycle
positive regulation of peptidyl-threonine phosphorylation
female meiosis chromosome segregation
protein ubiquitination
peptidyl-serine phosphorylation
regulation of mitotic metaphase/anaphase transition
protein destabilization
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
polar body extrusion after meiotic divisions
negative regulation of apoptotic process
regulation of protein binding
homologous chromosome segregation
establishment of protein localization
negative regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of proteolysis
response to antibiotic
centrosome organization
positive regulation of ubiquitin-protein transferase activity
protein localization to chromatin
positive regulation of ubiquitin protein ligase activity
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