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Invitrogen
Phospho-AKT (Thr308) Polyclonal Antibody
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产品信息
PA1-540
产品规格
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
Synthetic phosphopeptide corresponding to residues D(302) G A T M K T(p) F C G T P E(314) of mouse PKB.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
200 µg
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PA1-540 detects protein kinase B (PKB) from human, mouse, rat and drosophila samples.
PA1-540 has been successfully used in Western blotting procedures. By Western blot, this antibody detects an ~55 kDa protein representing both the phosphorylated and unphosphorylated forms of PKB in NIH-3T3 cell lysates, HeLa cell lysates, rat liver and drosophila samples..
PA1-540 immunogen is a synthetic phosphopeptide corresponding to residues D(302) G A T M K T(p) F C G T P E(314) of mouse PKB. PA1-540 immunizing peptide (Cat. # PEP-054) is available for use in neutralization and control experiments.
靶标信息
AKT1 (PKB alpha) is a serine/threonine kinase that regulates cell survival. The activated enzyme inhibits apoptosis and stimulates cell cycle progression by phosphorylating numerous targets in various cell types, including cancer cells. This protein kinase is activated by insulin, PI3K, IGF1 and various other growth and survival factors. Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including forkhead transcription factors, and caspase-9. The AKT pathway is a major target for cancer drug discovery.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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