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Invitrogen
PAR4 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA1-755
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic Peptide: C E(322) Q L K Q E N K T L L K V V G Q L T R(340)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
200 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA1-755 detects prostate apoptosis response protein (Par-4) from human and rat tissues.
PA1-755 has been sucessfully used in Western blot procedures. By Western blot, this antibody detects an ~40 kDa protein representing Par-4 in AT-3 cell extract. In Western blots of rat tissue extracts, including testes, spleen, ovary, lung, and skeletal muscle, ~40 kDa and ~38 kDa proteins representing Par-4 are detected. In Western blots of T47D cell extracts, an ~40 kDa protein representing Par-4 and a smaller ~20 kDa unknown protein is detected.
PA1-755 immunizing peptide corresponds to amino acids residues 322-340 from human Par-4. PA1-755 immunizing peptide (Cat. # PEP-060) is available for use in neutralization and control experiments.
靶标信息
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Par-4; par-4 induced by effectors of apoptosis; PRKC apoptosis WT1 regulator protein; prostate apoptosis response 4; Prostate apoptosis response 4 protein; Prostate apoptosis response protein 4; Transcriptional repressor Par-4-like protein PAWR
基因别名: Par-4; PAR4; PAWR
UniProt ID: (Rat) Q62627
Entrez Gene ID: (Rat) 64513
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
negative regulation of B cell proliferation
interleukin-2 biosynthetic process
negative regulation of T cell proliferation
positive regulation of amyloid precursor protein biosynthetic process
negative regulation of T cell receptor signaling pathway
actin filament bundle assembly
apoptotic signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
