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Invitrogen
Calreticulin Polyclonal Antibody
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图: 1 / 14
Calreticulin Antibody (PA1-902A) in WB
Western blot analysis was performed on membrane enriched extracts (30 µg lysate) of A-549 (Lane 1), HEK 293 (Lane 2) and Mouse Brain (Lane 3). The blot was probed with Anti-Calreticulin Chicken Polyclonal Antibody (Product # PA1-902A, 1:500-1:2000 dilution) and detected by chemiluminescence using Goat anti-Chicken IgY (H+L) Secondary Antibody, HRP conjugate (Product # A16054, 0.4 µg/mL, 1:2500 dilution). A 48 kDa band corresponding to Calreticulin was observed across the cell lines and tissue tested. Known quantity of protein samples were ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA1-902A
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Hamster,
Human,
Mouse,
Rat
已发表种属
Hamster,
Human,
Mouse
宿主/亚型
Chicken
/ IgY
分类
Polyclonal
类型
Antibody
抗原
Synthetic Peptide: K(24) E Q F L D G D A W T N R W V E S K H K(43).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.1 mg/mL
规格
110 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA1-902A detects calreticulin from canine, hamster, human, mouse and rat tissues.
PA1-902A has been successfully used in Western blot, immunocytochemistry and immunofluorescene procedures. By Western blot, this antibody detects an ~60-66 kDa protein representing calreticulin.
PA1-902A immunizing peptide corresponds to amino acid residues 24-43 from mouse calreticulin. PA1-902A immunizing peptide (Cat. # PEP-018) is available for use in neutralization and control experiments.
靶标信息
Calr or Calreticulin is a calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. Calr, a lectin, interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Calr also interacts with with the DNA-binding domain of NR3C1 and mediates its nuclear export. It may also be involved in maternal gene expression regulation and oocyte maturation via the regulation of calcium homeostasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Autoantigen RO; CABP3; CALBP; Calcium-binding protein 3; Calregulin; Calreticulin; CRP55; Endoplasmic reticulum resident protein 60; ERp60; FLJ26680; grp60; HACBP; Ro/SS-A Antigen
基因别名: CALR; Calregulin; CRP55; CRT; CRTC; ERp60; HACBP; I79_008346
UniProt ID: (Chinese hamster) Q8K3H7, (Mouse) P14211, (Rat) P18418
Entrez Gene ID: (Dog) 476694, (Chinese hamster) 100689096, (Mouse) 12317, (Rat) 64202
protein stabilization
negative regulation of transcription from RNA polymerase II promoter
peptide antigen assembly with MHC class I protein complex
protein folding
protein export from nucleus
cell cycle arrest
positive regulation of cell proliferation
positive regulation of gene expression
negative regulation of translation
cortical actin cytoskeleton organization
negative regulation of intracellular steroid hormone receptor signaling pathway
protein localization to nucleus
regulation of meiotic nuclear division
negative regulation of neuron differentiation
positive regulation of DNA replication
positive regulation of cell cycle
negative regulation of transcription, DNA-templated
negative regulation of retinoic acid receptor signaling pathway
positive regulation of phagocytosis
chaperone-mediated protein folding
cellular senescence
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of dendritic cell chemotaxis
spermatogenesis
response to organic substance
response to estradiol
response to testosterone
response to drug
cardiac muscle cell differentiation
cellular response to lithium ion
cellular response to organic substance
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