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Invitrogen
TBL1X/TBL1XR1 Polyclonal Antibody
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FIGURE: 1 / 1
TBL1X/TBL1XR1 Antibody (PA1-9108) in IHC (P)
Immunohistochemistry (PFA fixed) analysis of TBL1X/TBL1XR1 using TBL1X/TBL1XR1 Polyclonal Antibody (Product # PA1-9108) (4 µg/mL) in staining of paraffin embedded Human Kidney. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-9108
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the C terminus amino acids SASDGSVCVLDLRK (aa 564-577).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is expected to recognize the human protein TBL1XR1 (NP_078941) as well as TBL1X. Variants (NP_005638.1; NP_001132938.1) encode isoform a (TBL1X) and variants (NP_001132939.1; NP_001132940.1 ) encode isoform b (TBL1X).
This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 4,000.
Target Information
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; TBL1X receptor 1; transducin beta like 1 X-linked receptor 1; transducin beta like 1X-linked; transducin beta-like protein 1X; transducin-beta-like protein 1, X-linked; unnamed protein product
Gene Aliases: C21; CHNG8; DC42; EBI; IRA1; MRD41; SMAP55; TBL1; TBLR1
UniProt ID: (Human) O60907, (Human) Q9BZK7
Entrez Gene ID: (Human) 6907, (Human) 79718
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of canonical Wnt signaling pathway
proteolysis
sensory perception of sound
protein stabilization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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