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Invitrogen
NR3C2 Polyclonal Antibody
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Product Details
PA5-95019
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human NR3C2 (966-984aa DQLPKVESGNAKPLYFHRK).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
Steroid receptors are ligand-dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Mineralocorticoids are a family of steroids, secreted by the adrenal cortex, necessary for the regulation of a number of metabolic processes including electrolyte regulation. These compounds exert their effect through their interaction with the mineralocorticoid receptor (MR) and that complex's subsequent association with DNA. Given the function of mineralocorticoids, it is not surprising to find that the kidney is a primary target organ for mineralocorticoids and that this organ has been shown to contain MR. The corresponding gene for the mineralocorticoid receptor is NR3C2.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aldosterone receptor; mineralocorticoid receptor; Mineralocorticoid receptor (aldosterone receptor); mineralocorticoid receptor 1; mineralocorticoid receptor 2; mineralocorticoid receptor delta; MR; unnamed protein product
Gene Aliases: MCR; MLR; MR; NR3C2VIT
UniProt ID: (Human) P08235, (Rat) P22199
Entrez Gene ID: (Human) 4306, (Mouse) 110784, (Rat) 25672
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
TBP-class protein binding
estrogen response element binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
transcription coactivator binding
double-stranded DNA binding
steroid binding
histone acetyltransferase binding
identical protein binding
macromolecular complex binding
regulation of blood volume by renal aldosterone
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cellular sodium ion homeostasis
signal transduction
locomotory behavior
intracellular steroid hormone receptor signaling pathway
nuclear receptor-mediated corticosteroid signaling pathway
cellular response to hormone stimulus
renal sodium excretion
angiotensin-activated signaling pathway
regulation of cell proliferation
positive regulation of transcription from RNA polymerase II promoter
response to corticosterone
potassium ion homeostasis
regulation of postsynaptic membrane potential
presynaptic modulation of chemical synaptic transmission
positive regulation of NIK/NF-kappaB signaling
cellular response to aldosterone
regulation of potassium:proton exchanging ATPase activity
positive regulation of transcription, DNA-templated
response to alcohol
response to ketone
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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