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Invitrogen
ALOX5 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-95034
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human ALOX5 (650-667aa AERNKKKQLPYYYLSPDR).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: SW620 whole cell, JURKAT whole cell, COLO320 whole cell, A549 whole cell, MCF-7 whole cell. IHC: Human Lung Cancer Tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
This gene encodes a protein which, with Arachidonate 5-lipoxygenase-activating protein, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 5-LO; Arachidonate 5-lipoxygenase; arachidonic acid 5-lipoxygenase; leukotriene A4 synthase; lipoxygenase; LOX-5; lox5; Polyunsaturated fatty acid 5-lipoxygenase; RP11-67C2.3
基因别名: 5-LO; 5-LOX; 5LPG; ALOX5; LOG5
Entrez Gene ID: (Human) 240
arachidonate 5-lipoxygenase activity
arachidonate 12-lipoxygenase activity
iron ion binding
protein binding
oxidoreductase activity
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
arachidonate 8(S)-lipoxygenase activity
metal ion binding
long-chain fatty acid metabolic process
negative regulation of endothelial cell proliferation
leukocyte chemotaxis involved in inflammatory response
leukocyte migration involved in inflammatory response
icosanoid metabolic process
leukotriene metabolic process
response to stress
humoral immune response
negative regulation of angiogenesis
arachidonic acid metabolic process
leukotriene biosynthetic process
lipoxygenase pathway
positive regulation of bone mineralization
lipid oxidation
dendritic cell migration
glucose homeostasis
long-chain fatty acid biosynthetic process
regulation of fat cell differentiation
regulation of inflammatory response
negative regulation of inflammatory response
regulation of insulin secretion
negative regulation of vascular wound healing
negative regulation of wound healing
regulation of inflammatory response to wounding
regulation of cytokine production involved in inflammatory response
regulation of cellular response to oxidative stress
leukotriene A4 biosynthetic process
regulation of reactive oxygen species biosynthetic process
negative regulation of response to endoplasmic reticulum stress
negative regulation of sprouting angiogenesis
positive regulation of leukocyte adhesion to arterial endothelial cell
lipoxin biosynthetic process
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