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Invitrogen
BCL6 Polyclonal Antibody
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BCL6 Antibody (PA5-95591) in IHC (P)
Immunohistochemistry analysis of BCL6 in paraffin-embedded mouse spleen tissues. Antigen retrieval was performed on the tissue using citrate buffer (pH 6, 20 min) and blocked with 10% goat serum. Samples were incubated with BCL6 polyclonal antibody (Product # PA5-95591) at a 1 µg/mL dilution, followed by biotinylated goat anti-rabbit IgG (30 min, 37°C), and developed with Strepavidin-Biotin-Complex and DAB.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-95591
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence of human BCL6 (ASPADSCIQFTRHASDVLLNLNRLRSRDILTD).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
4mg trehalose, 0.9mg NaCl, 0.2mg Na2PO4
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Raji whole cell, human MCF-7 whole cell, human placenta tissue, human A549 whole cell, human Caco-2 whole cell, human U2OS whole cell, rat testis tissue, rat spleen tissue, rat brain tissue, mouse testis tissue, mouse spleen tissue, mouse brain tissue. IHC: human tonsil tissue, mouse spleen tissue. Flow: BRL cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
Bcl-6 proto-oncogene product (a Kruppel-type zinc-finger protein) is mainly expressed in normal germinal center B cells and related lymphomas. Bcl-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and Bcl-6 rearrangements have been detected in 33%-45% of diffuse large B cell lymphomas. Bcl-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B cell CLL/lymphoma 6; B-cell lymphoma 5 protein; B-cell lymphoma 5 protein (BCL5); B-cell lymphoma 6 protein; B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; cys his2 zinc finger transcription factor; cys-his2 zinc finger transcription factor; LAZ-3 protein; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3); lymphoma-associated zinc finger gene on chromosome 3; Protein LAZ-3; transcriptional repressor; B-cell CLL/lymphoma 6 spliced short isoform; transcriptional repressor; zinc finger protein 51; unnamed protein product; Zinc finger and BTB domain-containing protein 27; Zinc finger and BTB domain-containing protein 27 (ZBTB27); Zinc finger protein 51; Zinc Finger Protein 51 (ZNF51); zinc finger transcription factor BCL6S
基因别名: BCL5; BCL6; BCL6A; LAZ3; ZBTB27; ZNF51
Entrez Gene ID: (Human) 604
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
intronic transcription regulatory region sequence-specific DNA binding
transcription corepressor binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
chromatin DNA binding
identical protein binding
sequence-specific DNA binding
DNA-binding transcription factor binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
regulation of cytokine production
regulation of germinal center formation
regulation of immune system process
negative regulation of B cell apoptotic process
cellular response to DNA damage stimulus
negative regulation of cell growth
type 2 immune response
regulation of cell proliferation
regulation of apoptotic process
positive regulation of apoptotic process
regulation of T cell differentiation
positive regulation of regulatory T cell differentiation
regulation of cell differentiation
positive regulation of cell differentiation
negative regulation of transcription, DNA-templated
regulation of inflammatory response
regulation of immune response
positive regulation of lymphocyte activation
regulation of leukocyte cell-cell adhesion
negative regulation of mitotic cell cycle DNA replication
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