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Invitrogen
GFER Polyclonal Antibody
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GFER Antibody (PA5-100017) in IHC (P)
Immunohistochemistry analysis of GFER in human gastric cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with GFER polyclonal antibody (Product # PA5-100017) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-100017
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human GFER(Accession P55789), corresponding to amino acid residues C171-D205.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total ALR.
靶标信息
Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Augmenter of liver regeneration; FAD-linked sulfhydryl oxidase ALR; growth factor, erv1 homolog; growth factor, erv1-like (augmenter of liver regeneration); Hepatopoietin; hERV1
基因别名: ALR; ERV1; GFER; HERV1; HPO; MNCb-0663
UniProt ID: (Rat) Q63042, (Mouse) P56213
Entrez Gene ID: (Rat) 27100, (Mouse) 11692
response to lipopolysaccharide
negative regulation of apoptotic process
negative regulation of natural killer cell mediated cytotoxicity
oxidation-reduction process
cellular response to lipopolysaccharide
cellular response to tumor necrosis factor
cellular response to actinomycin D
cellular response to toxic substance
liver regeneration
negative regulation of oxidative stress-induced neuron death
positive regulation of DNA biosynthetic process
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