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Invitrogen
D2HGDH Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-100063
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human D2HGDH(Accession Q8N465), corresponding to amino acid residues E409-P459.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total D2HGDH.
靶标信息
This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: D-2-hydroxyglutarate dehydrogenase, mitochondrial; D2hgdh {ECO:0000250|UniProtKB:Q8N465}; FLJ42195; MGC25181
基因别名: AA408776; AA408778; AI325464; D2HGD; D2HGDH; RGD1307976
UniProt ID: (Mouse) Q8CIM3, (Rat) P84850
Entrez Gene ID: (Mouse) 98314, (Rat) 301624
catalytic activity
UDP-N-acetylmuramate dehydrogenase activity
oxidoreductase activity
oxidoreductase activity, acting on CH-OH group of donors
limonene-1,2-diol dehydrogenase activity
flavin adenine dinucleotide binding
(R)-2-hydroxyglutarate dehydrogenase activity
dehydrogenase
oxidoreductase
metabolite interconversion enzyme
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