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Invitrogen
SNAPAP Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-100078
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SNAPIN(Accession O95295), corresponding to amino acid residues M1-Q38.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SNAPIN.
Target Information
The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Biogenesis of lysosome-related organelles complex 1 subunit 7; BLOC-1 subunit 7; SNAP-associated protein; SNARE associated protein snapin; SNARE-associated protein Snapin; synaptosomal-associated protein 25 binding protein; Synaptosomal-associated protein 25-binding protein; synaptosomal-associated protein, 25 kDa, binding protein
Gene Aliases: 25kDa; AA407989; AV026596; BLOC1S7; SNAP25BP; SNAPAP; SNAPIN
UniProt ID: (Mouse) Q9Z266, (Rat) P60192
Entrez Gene ID: (Mouse) 20615, (Rat) 295217
intracellular protein transport
exocytosis
chemical synaptic transmission
anterograde axonal transport
endosome to lysosome transport
negative regulation of neuron projection development
synaptic vesicle exocytosis
synaptic vesicle maturation
calcium ion regulated exocytosis
neuron projection development
synaptic vesicle fusion to presynaptic active zone membrane
regulation of protein binding
synaptic vesicle transport
anterograde synaptic vesicle transport
terminal button organization
autophagosome maturation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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