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Invitrogen

Activin A Polyclonal Antibody

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View all (22) Activin A antibodies

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Activin A Polyclonal Antibody

Product Details

PA5-100101

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Published species

Non-human primate

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human INHBA(Accession P08476), corresponding to amino acid residues A281-K331.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2815631

Product Specific Information

Antibody detects endogenous levels of total Inhibin beta A.

Target Information

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Activin beta-A chain; beta-A inhibin; EDF; erythroid differentiation factor; Erythroid differentiation protein; erythroid differentiation protein precursor; follicle-stimulating hormone-releasing protein; FSH-releasing protein; Inhibin beta A chain; inhibin beta A subunit; inhibin, beta A (activin A, activin AB alpha polypeptide); Inhibin, beta-1; unnamed protein product

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Gene Aliases: EDF; FRP; INHBA

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UniProt ID: (Mouse) Q04998

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Entrez Gene ID: (Human) 3624, (Mouse) 16323

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Function(s)
receptor binding cytokine activity hormone activity protein binding growth factor activity peptide hormone binding identical protein binding macromolecular complex binding type II activin receptor binding protein sequestering activity transforming growth factor beta receptor binding inhibin binding protein heterodimerization activity growth factor
Process(es)
ovarian follicle development hair follicle development hematopoietic progenitor cell differentiation regulation of transcription from RNA polymerase II promoter autophagy defense response cell surface receptor signaling pathway transmembrane receptor protein serine/threonine kinase signaling pathway cell-cell signaling nervous system development negative regulation of cell proliferation male gonad development response to wounding positive regulation of gene expression cytokine-mediated signaling pathway striatal medium spiny neuron differentiation cell differentiation erythrocyte differentiation negative regulation of cell growth negative regulation of interferon-gamma production activin receptor signaling pathway negative regulation of activin receptor signaling pathway positive regulation of collagen biosynthetic process endodermal cell differentiation negative regulation of phosphorylation odontogenesis hemoglobin biosynthetic process progesterone secretion negative regulation of B cell differentiation positive regulation of erythrocyte differentiation negative regulation of macrophage differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase III promoter regulation of follicle-stimulating hormone secretion positive regulation of follicle-stimulating hormone secretion negative regulation of follicle-stimulating hormone secretion cell development animal organ development system development positive regulation of protein metabolic process palate development positive regulation of ovulation positive regulation of SMAD protein import into nucleus SMAD protein signal transduction cardiac fibroblast cell development eyelid development in camera-type eye positive regulation of ERK1 and ERK2 cascade cellular response to follicle-stimulating hormone stimulus cellular response to cholesterol cellular response to hypoxia cellular response to oxygen-glucose deprivation GABAergic neuron differentiation extrinsic apoptotic signaling pathway response to aldosterone cellular response to angiotensin negative regulation of G1/S transition of mitotic cell cycle positive regulation of extrinsic apoptotic signaling pathway in absence of ligand G1/S transition of mitotic cell cycle mesoderm formation cell cycle arrest positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of cellular protein metabolic process growth response to drug regulation of apoptotic process regulation of MAPK cascade negative regulation of cell cycle mesodermal cell differentiation negative regulation of hair follicle development
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