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Invitrogen
Folliculin Polyclonal Antibody
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FIGURE: 1 / 3
Folliculin Antibody (PA5-100247) in ICC/IF
Immunofluorescent analysis of Folliculin in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Folliculin polyclonal antibody (Product # PA5-100247) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 4... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-100247
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human FLCN(Accession Q8NFG4), corresponding to amino acid residues S56-Y106.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total FLCN.
Target Information
This gene encodes a mitochondrial protein that is characterized by a poly-proline rich region. A chicken homolog of this protein promotes mitochondrial fission and the mouse homolog protects cells from oxidative stress. A related pseudogene of this gene is found on chromosome X.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Birt-Hogg-Dube syndrome protein homolog; Folliculin
Gene Aliases: AU014660; B430214A04Rik; Bhd; FLCL; Flcn
UniProt ID: (Mouse) Q8QZS3, (Rat) Q76JQ2
Entrez Gene ID: (Mouse) 216805, (Rat) 303185
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
regulation of protein phosphorylation
positive regulation of protein phosphorylation
cell-cell junction assembly
negative regulation of gene expression
negative regulation of mitochondrion organization
negative regulation of angiogenesis
hemopoiesis
negative regulation of cell growth
negative regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
TOR signaling
regulation of TOR signaling
negative regulation of TOR signaling
positive regulation of TOR signaling
regulation of cytokinesis
negative regulation of Rho protein signal transduction
regulation of histone acetylation
positive regulation of cell adhesion
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of protein kinase B signaling
negative regulation of ERK1 and ERK2 cascade
negative regulation of protein localization to nucleus
negative regulation of cell proliferation involved in kidney development
negative regulation of cellular respiration
negative regulation of mitochondrial DNA metabolic process
negative regulation of muscle tissue development
negative regulation of post-translational protein modification
negative regulation of energy homeostasis
regulation of pro-B cell differentiation
negative regulation of ATP biosynthetic process
positive regulation of intrinsic apoptotic signaling pathway
biological_process
positive regulation of apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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