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Invitrogen
PPARGC1B Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-100305
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PPARGC1B(Accession Q86YN6), corresponding to amino acid residues H658-V708.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total PPARGC1B.
靶标信息
PGC-1 beta is a tissue specific co-activator that enhances the activity of estrogen receptor alpha. The co-activation function relies on a bipartite transcriptional activation domain and two LXXLL motifs that interact with the AR2 domain of ER-alpha in an estrogen-dependent manner. Ectopic expression of this protein has been shown to lead to increased mitochondrial number and basal oxygen consumption.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ERR ligand 1; peroxisome proliferator-activated receptor gamma coactivator 1 beta; Peroxisome proliferator-activated receptor gamma coactivator 1-beta; pgc-1 beta; PGC-1-beta; PGC-1beta; PGC-1beta/ERRL1; PPAR gamma coactivator-1beta protein; PPAR-gamma coactivator 1-beta; PPARGC-1-beta
基因别名: 4631412G21Rik; Errl1; Perc; Pgc1; Pgc1b; Ppargc1; Ppargc1b
UniProt ID: (Mouse) Q8VHJ7
Entrez Gene ID: (Mouse) 170826
nucleotide binding
RNA polymerase II transcription cofactor activity
nucleic acid binding
RNA binding
protein binding
transcription factor binding
estrogen receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
receptor activator activity
AF-2 domain binding
transcription cofactor
ossification
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
transcription from mitochondrial promoter
actin filament organization
positive regulation of alkaline phosphatase activity
intracellular estrogen receptor signaling pathway
cellular response to reactive oxygen species
positive regulation of phosphorylation
positive regulation of osteoclast differentiation
positive regulation of bone resorption
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
bone trabecula formation
positive regulation of receptor activity
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