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Invitrogen
EXOSC10 Polyclonal Antibody
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EXOSC10 Antibody (PA5-100508) in IHC (P)
Immunohistochemistry analysis of EXOSC10 in rat brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with EXOSC10 polyclonal antibody (Product # PA5-100508) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-100508
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human EXOSC10(Accession Q01780), corresponding to amino acid residues T196-T246.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total EXOSC10.
靶标信息
About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome are reported to have autoantibodies to a nuclear/nucleolar particle termed PM-Scl. Exosome component 10 (EXOSC10), also named autoantigen PM/Scl-2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl patients. EXOSC10 is strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. As a putative catalytic component ofthe RNA exosome complex which has 3'->5' exoribonuclease activity, EXOSC10 participates in a multitude of cellular RNA processing and degradation events.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Autoantigen PM/Scl 2; Autoantigen PM/Scl 2 homolog; Exosome complex component 10; exosome component 10; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; PM/Scl-100; Polymyositis/scleroderma autoantigen 100 kDa; Polymyositis/scleroderma autoantigen 2; Polymyositis/scleroderma autoantigen 2 homolog
基因别名: EXOSC10; p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL; PMSCL2; RRP6
UniProt ID: (Mouse) P56960, (Rat) D4A1X2
Entrez Gene ID: (Mouse) 50912, (Rat) 313707
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
maturation of 5.8S rRNA
nuclear-transcribed mRNA catabolic process
nucleobase-containing compound metabolic process
rRNA processing
RNA processing
dosage compensation by inactivation of X chromosome
cellular metabolic process
nuclear mRNA surveillance
CUT catabolic process
nuclear polyadenylation-dependent rRNA catabolic process
histone mRNA catabolic process
nuclear retention of unspliced pre-mRNA at the site of transcription
RNA phosphodiester bond hydrolysis, exonucleolytic
nucleic acid phosphodiester bond hydrolysis
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