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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Antibody detects endogenous levels of total Granzyme K.
Granzyme K (GrK) belongs to a family of trypsin-like serine proteases localised in the cytotoxic granules of activated T cells and NK cells. It encodes a 28 kDa serine protease whose gene is located on chromosome 5q11-12 close to the granzyme A-encoding gene. Like granzyme A, it has a trypsin-like specifity cleaving at the basic residues arginine and lysine. Granzyme K triggers rapid cell death independently of caspase activation with single-stranded DNA nicks and is primarily expressed in thymus, lung, spleen and peripheral blood leukocytes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Fragmentin-3; Granzyme K; Granzyme-3; GrK; NK-Tryp-2; NK-tryptase-2; RNK-Tryp-2
基因别名: GZMK; TRYP2
UniProt ID: (Mouse) O35205, (Rat) P49864
Entrez Gene ID: (Mouse) 14945, (Rat) 29165