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Invitrogen
HNF4A/HNF4G Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-100879
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human HNF4A(Accession P41235), corresponding to amino acid residues A287-L337.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total HNF4 alpha /gamma.
靶标信息
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha transcription factor 4; hepatic nuclear factor 4, alpha; Hepatocyte nuclear factor 4-alpha; Hepatocyte nuclear factor 4-gamma; HNF-4-alpha; HNF-4-gamma; HNF4 alpha; HNF4alpha10; HNF4alpha11; HNF4alpha12; Nuclear receptor 2A1; Nuclear receptor subfamily 2 group A member 1; Nuclear receptor subfamily 2 group A member 2; TCF-14; Transcription factor 14; Transcription factor HNF-4
基因别名: HNF-4; HNF4; HNF4A; Hnf4alpha; HNF4G; MODY1; NR2A1; NR2A2; TCF14
UniProt ID: (Mouse) P49698, (Rat) P22449, (Mouse) Q9WUU6
Entrez Gene ID: (Mouse) 15378, (Rat) 25735, (Mouse) 30942, (Rat) 365744
fatty-acyl-CoA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II activating transcription factor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
receptor binding
fatty acid binding
protein binding
transcription factor binding
zinc ion binding
palmitoyl-CoA hydrolase activity
protein homodimerization activity
sequence-specific DNA binding
transcription regulatory region DNA binding
metal ion binding
repressing transcription factor binding
C4 zinc finger nuclear receptor
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
ornithine metabolic process
lipid metabolic process
acyl-CoA metabolic process
xenobiotic metabolic process
establishment of tissue polarity
sex differentiation
blood coagulation
negative regulation of cell proliferation
response to glucose
regulation of gastrulation
regulation of lipid metabolic process
signal transduction involved in regulation of gene expression
cell differentiation
negative regulation of cell growth
regulation of microvillus assembly
negative regulation of protein import into nucleus, translocation
negative regulation of tyrosine phosphorylation of Stat5 protein
glucose homeostasis
steroid hormone mediated signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
cell-cell junction organization
positive regulation of gluconeogenesis
positive regulation of fatty acid biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
regulation of insulin secretion
lipid homeostasis
phospholipid homeostasis
SMAD protein signal transduction
triglyceride homeostasis
negative regulation of activation of JAK2 kinase activity
positive regulation of cholesterol homeostasis
intracellular receptor signaling pathway
response to drug
response to cAMP
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