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Invitrogen
Phospho-CDK1/CDK2 (Thr14) Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-101016
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CDK1(Accession P06493), corresponding to amino acid residues around phosphorylated Thr14.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of Cdk1/2 only when phosphorylated at Thr14.
Target Information
Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cdc2-related protein kinase; CDK2; cell cycle controller CDC2; cell cycle p34 CDC2 kinase protein; cell division control protein 2 homolog; cell division cycle 2 homolog A; cell division cycle 2, G1 to S and G2 to M; Cell division cycle control protein 2; cell division cycle control protein 2a; cell division protein kinase 1; cell division protein kinase 2; cyclin dependent kinase 2-alpha; p33 protein kinase; p34 protein kinase; unnamed protein product
Gene Aliases:
A630093N05Rik; CDC2; CDC28A; Cdc2a; CDKN2; p33(CDK2); p34
UniProt ID: (Human) P06493, (Human) P24941, (Mouse) P11440, (Rat) P39951, (Mouse) P97377
Entrez Gene ID: (Human) 983, (Human) 1017, (Mouse) 12534, (Rat) 54237, (Rat) 362817, (Mouse) 12566
chromatin binding
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
RNA polymerase II carboxy-terminal domain kinase activity
kinase activity
cyclin binding
Hsp70 protein binding
histone kinase activity
cyclin-dependent protein kinase activity
protein serine kinase activity
magnesium ion binding
protein domain specific binding
macromolecular complex binding
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
microtubule cytoskeleton organization
DNA replication
DNA repair
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
mitotic nuclear envelope disassembly
mitotic G2 DNA damage checkpoint
centrosome cycle
pronuclear fusion
response to toxic substance
positive regulation of gene expression
positive regulation of G2/M transition of mitotic cell cycle
regulation of Schwann cell differentiation
response to amine
response to activity
cell migration
protein deubiquitination
peptidyl-threonine phosphorylation
chromosome condensation
epithelial cell differentiation
negative regulation of protein ubiquitination
protein localization to kinetochore
positive regulation of protein import into nucleus
response to hydrogen peroxide
regulation of circadian rhythm
negative regulation of apoptotic process
response to ethanol
positive regulation of DNA replication
positive regulation of smoothened signaling pathway
regulation of embryonic development
response to cadmium ion
response to copper ion
response to axon injury
ventricular cardiac muscle cell development
positive regulation of cardiac muscle cell proliferation
positive regulation of mitotic sister chromatid segregation
protein-containing complex assembly
cellular response to hydrogen peroxide
ERK1 and ERK2 cascade
Golgi disassembly
regulation of heterochromatin organization
positive regulation of protein localization to nucleus
regulation of mitotic attachment of spindle microtubules to kinetochore
microtubule cytoskeleton organization involved in mitosis
positive regulation of mitochondrial ATP synthesis coupled electron transport
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
protein phosphorylation
nuclear envelope organization
cell proliferation
negative regulation of gene expression
peptidyl-serine phosphorylation
mitotic cell cycle phase transition
thymidine biosynthetic process
microtubule polymerization
cilium disassembly
DNA strand resection involved in replication fork processing
DNA synthesis involved in mitotic DNA replication
protein localization to site of double-strand break
mitotic DNA-dependent DNA replication
negative regulation of transcription from RNA polymerase II promoter
lens development in camera-type eye
potassium ion transport
centriole replication
signal transduction
Ras protein signal transduction
positive regulation of cell proliferation
response to xenobiotic stimulus
positive regulation of heterochromatin assembly
positive regulation of DNA-dependent DNA replication initiation
response to estradiol
cellular response to insulin stimulus
negative regulation of protein catabolic process
telomere maintenance in response to DNA damage
post-translational protein modification
positive regulation of transcription, DNA-templated
response to cAMP
response to electrical stimulus
liver regeneration
negative regulation of protein localization to chromatin
positive regulation of meiotic cell cycle process involved in oocyte maturation
meiotic spindle organization
meiotic cell cycle process involved in oocyte maturation
regulation of mitotic cell cycle
mitotic G1 DNA damage checkpoint
centrosome duplication
meiotic cell cycle
cellular response to nitric oxide
cellular senescence
regulation of anaphase-promoting complex-dependent catabolic process
telomere maintenance
protection from non-homologous end joining at telomere
regulation of cell cycle
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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