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Invitrogen
ID4 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-101114
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ID4(Accession P47928), corresponding to amino acid residues M1-G36.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total ID4.
靶标信息
ID4 is transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bHLHb27; Class B basic helix-loop-helix protein 27; DNA-binding protein inhibitor ID-4; Inhibitor of differentiation 4; Inhibitor of DNA binding 4
基因别名: BHLHB27; Id-4; ID4; Idb4
UniProt ID: (Mouse) P41139
Entrez Gene ID: (Rat) 291023, (Mouse) 15904
G1/S transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
neuroblast proliferation
brain development
circadian rhythm
cell proliferation
positive regulation of cell proliferation
hippocampus development
cerebral cortex neuron differentiation
central nervous system myelination
cellular protein localization
fat cell differentiation
negative regulation of fat cell differentiation
negative regulation of neuron differentiation
positive regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of astrocyte differentiation
negative regulation of oligodendrocyte differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
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