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Invitrogen
COL11A1 Polyclonal Antibody
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Product Details
PA5-101300
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human COL11A1(Accession P12107), corresponding to amino acid residues M590-G640.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Collagen XI alpha 1.
Target Information
Collagen Type XI is an 1806 amino acid protein belonging to the fibrillar collagen family. Collagen Type XI is thought to play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. This protein forms trimers composed of three different chains: a 1(XI), a 2(XI), and a 3(XI). a 3(XI) is a post-translational modification of a 1(II). a 1(V) can also be found instead of a 3(XI). Collagen Type XI has three named isoforms (A,B,C) and additional isoforms seem to exist, stemming from alternative usage of exon IIA or exon IIB. Transcripts containing exon IIA or IIB are present in cartilage, but exon IIB is preferentially utilized in transcripts from tendon. Collagen Type XI contains a single collagen binding TSP N-terminal (TSPN) domain. Collagen Type XI is expressed in cartilage, placenta and some tumor or virally transformed cell lines. Isoform expression can be tissue specific. Defects in the COL11A gene are the cause of Stickler syndrome type 2 (STL2), or beaded vitreous type, due to the presence of irregularly thickened fiber bundles throughout vitreous cavity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: a1(XI) collagen; alpha-1 (type XI) collagen precursor; chondrodysplasia; COBA1; Collagen alpha 1; Collagen alpha-1(XI) chain; collagen XI, alpha-1 polypeptide; collagen, type XI, alpha 1; deafness, autosomal dominant 37; pro-alpha1(XI) collagen; procollagen, type XI, alpha 1; STL3; unnamed protein product; XI chain precursor
Gene Aliases: C530001D20Rik; cho; CO11A1; COL11A1; COLL6; DFNA37; STL2
UniProt ID: (Human) P12107, (Mouse) Q61245
Entrez Gene ID: (Human) 1301, (Mouse) 12814
cartilage condensation
chondrocyte development
heart morphogenesis
proteoglycan metabolic process
visual perception
sensory perception of sound
collagen fibril organization
endodermal cell differentiation
tendon development
inner ear morphogenesis
embryonic skeletal system morphogenesis
skeletal system morphogenesis
detection of mechanical stimulus involved in sensory perception of sound
cartilage development
ventricular cardiac muscle tissue morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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