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Invitrogen
CYP1A1/CYP1A2 Polyclonal Antibody
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FIGURE: 1 / 3
CYP1A1/CYP1A2 Antibody (PA5-101307) in ICC/IF
Immunofluorescence analysis of Cytochrome P450 1A1/A2 was performed using T-47D cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with CYP1A1 Polyclonal Antibody (Product # PA5-101307) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnigh... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-101307
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CYP1A1(Accession P04798), corresponding to amino acid residues I78-G128.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Cytochrome P450 1A1/2.
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aromatic compound inducible; aryl hydrocarbon hydroxylase; Cholesterol 25-hydroxylase; CYP1A1; CYPIA1; CYPIA2; Cytochrome P(3)450; Cytochrome P-448; Cytochrome P-450d; cytochrome P1-450; Cytochrome P3 450; Cytochrome P450 1A1; Cytochrome P450 1A2; Cytochrome P450 4; cytochrome P450 family 1 subfamily a polypeptide 1; cytochrome P450 family 1 subfamily a polypeptide 2; Cytochrome P450 form 6; cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c); Cytochrome P450 subfamily I (aromatic compound-inducible) member A2 (Q42 form d); cytochrome P450 subfamily I, polypeptide 1; cytochrome P450, 1a1; cytochrome P450, 1a1, aromatic compound inducible; cytochrome P450, 1a2; cytochrome P450, 1a2, aromatic compound inducible; cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c) (C6, form c); cytochrome P450, subfamily I (aromatic compound-inducible), member A2 (Q42, form d); Cytochrome P450-C; Cytochrome P450-D; Cytochrome P450-P1; Cytochrome P450-P2; Cytochrome P450-P3; Cytochrome P450MT2; dioxin-inducible; flavoprotein-linked monooxygenase; Hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P-448; P450-D; P450form6; P450MT2; xenobiotic monooxygenase
Gene Aliases: AHH; AHRR; CP11; CP12; CYP1; Cyp1a-1; Cyp1a-2; CYP1A1; CYP1A2; Cyp45c; Cypc45c; CYPD45; P-450d; P-450MC; P1-450; P450-1; P450-3; P450-C; P450DX; RATCYPD45
UniProt ID: (Mouse) P00184, (Rat) P00185, (Mouse) P00186, (Rat) Q64588
Entrez Gene ID: (Mouse) 13076, (Rat) 24296, (Mouse) 13077, (Rat) 24297
catalytic activity
monooxygenase activity
iron ion binding
steroid hydroxylase activity
oxidoreductase activity
oxidoreductase activity, acting on diphenols and related substances as donors
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
flavonoid 3'-monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
enzyme binding
heme binding
demethylase activity
metal ion binding
aromatase activity
vitamin D 24-hydroxylase activity
protein binding
caffeine oxidase activity
porphyrin-containing compound metabolic process
amine metabolic process
toxin metabolic process
response to toxic substance
coumarin metabolic process
flavonoid metabolic process
insecticide metabolic process
drug metabolic process
dibenzo-p-dioxin metabolic process
dibenzo-p-dioxin catabolic process
9-cis-retinoic acid biosynthetic process
heterocycle metabolic process
hydrogen peroxide biosynthetic process
oxidation-reduction process
demethylation
cellular response to organic cyclic compound
positive regulation of G1/S transition of mitotic cell cycle
steroid catabolic process
cellular aromatic compound metabolic process
toxin biosynthetic process
post-embryonic development
alkaloid metabolic process
regulation of gene expression
monoterpenoid metabolic process
lung development
monocarboxylic acid metabolic process
drug catabolic process
exogenous drug catabolic process
cellular respiration
oxidative demethylation
cellular response to cadmium ion
oxidative deethylation
response to hypoxia
liver development
aging
cell proliferation
response to wounding
response to virus
response to nematode
response to herbicide
embryo development ending in birth or egg hatching
response to organic substance
response to iron(III) ion
response to organic cyclic compound
response to food
response to lipopolysaccharide
developmental process
response to vitamin A
response to immobilization stress
response to drug
camera-type eye development
response to antibiotic
response to arsenic-containing substance
digestive tract development
response to hyperoxia
maternal process involved in parturition
hepatocyte differentiation
xenobiotic metabolic process
response to estradiol
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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