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Invitrogen
MYO5A Polyclonal Antibody
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图: 1 / 2
MYO5A Antibody (PA5-101689) in ICC/IF
Immunocytochemistry analysis of MYO5A in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with MYO5A polyclonal antibody (Product # PA5-101689) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-101689
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MYO5A(Accession Q9Y4I1), corresponding to amino acid residues L1783-P1833.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total MYO5A.
靶标信息
This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: dilute lethal-20J protein; Dilute myosin heavy chain, non-muscle; dilute-opisthotonus; flailer; myosin 5a; Myosin heavy chain 12; Myosin-12; myosin-Va; Myoxin; OTTMUSP00000017756; OTTMUSP00000019176; OTTMUSP00000046608; Unconventional myosin-Va
基因别名: 9630007J19Rik; AI413174; AI661011; D; d-120J; Dbv; Dilute; Dop; flail; flr; MVa; MYH12; Myo5; MYO5A; MyoVA; Sev-1
UniProt ID: (Mouse) Q99104, (Rat) Q9QYF3
Entrez Gene ID: (Mouse) 17918, (Rat) 25017
microfilament motor activity
SNARE binding
nucleotide binding
motor activity
actin binding
calcium ion binding
protein binding
calmodulin binding
ATP binding
syntaxin-1 binding
Rab GTPase binding
ATP-dependent protein binding
poly(A) RNA binding
protein heterodimerization activity
protein dimerization activity
calcium-dependent protein binding
actin binding motor protein
melanin metabolic process
transport
exocytosis
post-Golgi vesicle-mediated transport
chemical synaptic transmission
visual perception
metabolic process
protein transport
vesicle-mediated transport
regulation of exocytosis
actin filament-based movement
vesicle transport along actin filament
insulin secretion
melanocyte differentiation
regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
locomotion involved in locomotory behavior
secretory granule localization
melanosome localization
melanosome transport
cellular response to insulin stimulus
odontogenesis
myelination
anagen
long-chain fatty acid biosynthetic process
pigmentation
developmental pigmentation
synapse organization
neuromuscular process controlling balance
endoplasmic reticulum localization
protein localization to plasma membrane
regulation of Golgi organization
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