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Invitrogen
alpha Adducin Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-102434
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ADD1(Accession P35611), corresponding to amino acid residues G700-S737.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total ADD1.
靶标信息
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ADD2; ADDB; adducin 1 (alpha); Adducin beta; Adducin-1; Adducin-alpha; Adducin-beta; Adducin1; Alpha adducin; alpha-ADD; Alpha-adducin; alpha-adducin 1; beta Adducin; Beta-adducin; calmodulin-binding protein; erythrocyte adducin alpha subunit; Erythrocyte adducin subunit alpha; unnamed protein product
基因别名: ADD1; ADDA; AI256389
UniProt ID: (Mouse) Q9QYC0, (Rat) Q63028
Entrez Gene ID: (Human) 118, (Mouse) 11518, (Rat) 24170
RNA binding
actin binding
protein binding
cytoskeletal adaptor activity
spectrin binding
protein homodimerization activity
cadherin binding
protein heterodimerization activity
protein dimerization activity
actin filament binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
structural molecule activity
calmodulin binding
transcription factor binding
T cell receptor binding
poly(A) RNA binding
non-motor actin binding protein
cytoskeleton organization
actin cytoskeleton organization
regulation of actin filament polymerization
regulation of cellular component size
barbed-end actin filament capping
actin filament bundle assembly
positive regulation of developmental process
positive regulation of cellular component organization
cellular response to calcium ion
positive regulation of establishment of endothelial barrier
positive regulation of adherens junction organization
regulation of multicellular organismal development
cell morphogenesis
in utero embryonic development
cell volume homeostasis
hemoglobin metabolic process
erythrocyte differentiation
negative regulation of actin filament polymerization
positive regulation of protein binding
multicellular organism growth
positive regulation of angiogenesis
positive regulation of endocytosis
homeostasis of number of cells within a tissue
cellular response to retinoic acid
ion transport
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