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Invitrogen
IL24 Polyclonal Antibody
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IL24 Antibody (PA5-102507) in IHC (P)
Immunohistochemistry analysis of IL24 in human kidney cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with IL24 polyclonal antibody (Product # PA5-102507) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-102507
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human IL24(Accession Q13007), corresponding to amino acid residues L108-E158.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total IL24.
靶标信息
Interleukin 24 (IL-24)/melanoma differentiation-associated gene-7 (mda-7) encodes a secreted protein that exhibits significant homology to the interleukin 10 (IL-10) family of cytokines. The human IL-24 is secreted by activated peripheral blood mononuclear cells and binds two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2 resulting in the activation of JAK/STAT signaling pathways. Mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cytokine-like protein Mob-5; IL 24; IL-24; IL-4-induced secreted protein; Interleukin; Interleukin-24; MDA-7; Melanoma differentiation-associated gene 7 protein; Suppression of tumorigenicity 16 protein; Th2-specific cytokine FISP
基因别名: FISP; IL24; Mda-7; MDA7; Mob5; ST16
UniProt ID: (Rat) Q9JI24, (Mouse) Q925S4
Entrez Gene ID: (Rat) 170819, (Mouse) 93672
inflammatory response
immune response
positive regulation of cell proliferation
negative regulation of cell proliferation
negative regulation of cell migration
serine phosphorylation of STAT3 protein
wound healing
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to lipopolysaccharide
cellular response to interleukin-4
apoptotic process
positive regulation of JAK-STAT cascade
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