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Invitrogen
Glypican 3 Polyclonal Antibody
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图: 1 / 6
Glypican 3 Antibody (PA5-102528) in ICC/IF
Immunofluorescent analysis of Glypican 3 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Glypican 3 polyclonal antibody (Product # PA5-102528) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 4... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-102528
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human GPC3(Accession P51654), corresponding to amino acid residues R39-M89.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total GPC3.
靶标信息
GPC3 is a cell surface proteoglycan that bears heparan sulfate. This protein may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. Members of the glypican-related integral membrane proteoglycan family contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol (GPI) linkage. These proteins may play a role in the control of cell division, growth regulation, and tumor predisposition. Deletion mutations in GPC3 are the cause of Simpson-Golabi-Behmel syndrome (SGBS), also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cell surface protein; precursor core protein cleaved by furin; defective in Simpson-Golabi-Behmel overgrowth syndrome; glypican proteoglycan 3; Glypican-3; GTR2-2; GTR22; heparan sulphate proteoglycan; Intestinal protein OCI-5; MXR7; OCI-5; proteoglycan GPC3; secreted glypican-3; unnamed protein product
基因别名: DGSX; GPC3; GTR2-2; MXR7; OCI-5; OCI5; SDYS; SGB; SGBS; SGBS1
UniProt ID: (Rat) P13265, (Mouse) Q8CFZ4
Entrez Gene ID: (Human) 2719, (Rat) 25236, (Mouse) 14734
anatomical structure morphogenesis
regulation of signal transduction
cell migration
cell migration involved in gastrulation
positive regulation of protein catabolic process
positive regulation of endocytosis
negative regulation of smoothened signaling pathway
regulation of canonical Wnt signaling pathway
coronary vasculature development
cell proliferation involved in kidney development
mesenchymal cell proliferation involved in ureteric bud development
mesonephric duct morphogenesis
positive regulation of canonical Wnt signaling pathway
regulation of protein localization to membrane
regulation of non-canonical Wnt signaling pathway
branching involved in ureteric bud morphogenesis
kidney development
biological_process
negative regulation of cell proliferation
organ morphogenesis
anterior/posterior axis specification
body morphogenesis
negative regulation of peptidase activity
bone mineralization
osteoclast differentiation
lung development
positive regulation of BMP signaling pathway
embryonic hindlimb morphogenesis
regulation of growth
positive regulation of smoothened signaling pathway
negative regulation of growth
positive regulation of glucose import
negative regulation of epithelial cell proliferation
cell proliferation involved in metanephros development
negative regulation of canonical Wnt signaling pathway
positive regulation of Wnt signaling pathway, planar cell polarity pathway
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