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Invitrogen
CHI3L1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-102703
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CHI3L1(Accession P36222), corresponding to amino acid residues A251-D301.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total CHI3L1.
靶标信息
Human cartilage glycoprotein 39 (GP-39), also known as YKL-40, is a glycoprotein secreted by articular chondrocytes, synoviocytes and macrophages. Serum and synovial fluid GP-39 levels are elevated in inflammatory diseases and correlate with the degree of joint destruction in rheumatoid arthritis. GP-39 is expressed in articular chondrocytes and synovial cells, as well as in liver, but is undetectable in muscle tissues, lung, pancreas, mononuclear cells and fibroblasts. GP-39 is a candidate autoantigen in rheumatoid arthritis and is important in the capacity of cells to respond to and cope with changes in their environment.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 39 kDa synovial protein; Breast regression protein 39; BRP39 protein; Cartilage glycoprotein 39; CGP-39; CGP39; Chitinase 3 like protein 1CGP 39; chitinase 3-like 1; chitinase 3-like 1 protein; Chitinase-3-like protein 1; DKFZp686N19119; FLJ38139; GP-39; hCGP39; YKL-40
基因别名: AW208766; Brp39; CHI3L1; Chil1; Gp39
UniProt ID: (Rat) Q9WTV1, (Mouse) Q61362
Entrez Gene ID: (Rat) 89824, (Mouse) 12654
carbohydrate metabolic process
chitin catabolic process
apoptotic process
inflammatory response
immune response
activation of NF-kappaB-inducing kinase activity
response to mechanical stimulus
positive regulation of peptidyl-threonine phosphorylation
lung development
response to tumor necrosis factor
positive regulation of angiogenesis
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
response to interleukin-1
response to interleukin-6
cellular response to interleukin-1
cellular response to tumor necrosis factor
interleukin-8 secretion
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
