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Invitrogen
Calsequestrin 2 Polyclonal Antibody
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图: 1 / 4
Calsequestrin 2 Antibody (PA5-102970) in ICC/IF
Immunocytochemistry analysis of Calsequestrin 2 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Calsequestrin 2 polyclonal antibody (Product # PA5-102970) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-102970
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CASQ2(Accession O14958), corresponding to amino acid residues A272-F322.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total CASQ2.
靶标信息
Calsequestrin (CASQ) is a Ca2+-binding protein present primarily in junctional sarcoplasmic reticulum of skeletal and cardiac muscle; the cardiac form (CASQ2) is encoded by a separate gene. The primary role of CASQ2 is buffering of the sarcoplasmic reticulum Ca2+ ions, but another role for CASQ2 has emerged recently: CASQ2 regulates the open probability of ryanodine receptor 2 (RyR2). Mutations in CASQ2 cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: calsequestrin 2 (cardiac muscle); calsequestrin 2, fast-twitch, cardiac muscle; Calsequestrin, cardiac muscle isoform; Calsequestrin-2; cardiac calsequestrin; SR calcium binding protein; unnamed protein product
基因别名: AA033488; AW146219; cardCSQ; CASQ2; cCSQ; Csq2; ESTM52; PDIB2
UniProt ID: (Mouse) O09161, (Rat) P51868
Entrez Gene ID: (Human) 845, (Mouse) 12373, (Rat) 29209
regulation of heart rate
detection of calcium ion
cellular calcium ion homeostasis
striated muscle contraction
regulation of cell communication by electrical coupling
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
negative regulation of potassium ion transport
sarcomere organization
protein polymerization
regulation of release of sequestered calcium ion into cytosol
cardiac muscle contraction
regulation of membrane repolarization
cellular response to caffeine
Purkinje myocyte to ventricular cardiac muscle cell signaling
regulation of membrane repolarization during ventricular cardiac muscle cell action potential
regulation of muscle contraction
sequestering of calcium ion
negative regulation of ryanodine-sensitive calcium-release channel activity
regulation of cardiac muscle cell contraction
negative regulation of potassium ion transmembrane transporter activity
biological_process
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