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Invitrogen
KCNMA1 Polyclonal Antibody
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KCNMA1 Antibody (PA5-103145) in IHC (P)
Immunohistochemistry analysis of KCNMA1 in human pancreatic cancer and adjacent normal tissues. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with KCNMA1 polyclonal antibody (Product # PA5-103145) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-103145
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human KCNMA1(Accession Q12791), corresponding to amino acid residues S778-L828.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total MaxiK alpha.
靶标信息
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BK channel; BK channel alpha subunit; BKCA alpha; calcium-activated potassium channel alpha subunit; Calcium-activated potassium channel subunit alpha-1; Calcium-activated potassium channel, subfamily M subunit alpha-1; K(VCA)alpha; KCa1.1; Maxi K channel; MaxiK; mSlo1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; Slo homolog; Slo-alpha; Slo1; Slowpoke homolog
基因别名: 5730414M22Rik; BKCa; KCNMA; KCNMA1; KCNMA1b; KCNMA1c; MaxiK; mSlo; mSlo1; SLO; Slo1
UniProt ID: (Mouse) Q08460, (Rat) Q62976
Entrez Gene ID: (Mouse) 16531, (Rat) 83731
actin binding
ion channel activity
voltage-gated ion channel activity
voltage-gated potassium channel activity
potassium channel activity
protein binding
calcium-activated potassium channel activity
protein complex binding
protein homodimerization activity
metal ion binding
large conductance calcium-activated potassium channel activity
ion channel
response to hypoxia
transport
ion transport
potassium ion transport
response to osmotic stress
chemical synaptic transmission
sensory perception of sound
circadian rhythm
adult walking behavior
response to pH
neuronal action potential
cellular potassium ion homeostasis
response to corticosteroid
regulation of aldosterone metabolic process
response to carbon monoxide
regulation of ion transmembrane transport
vasodilation
regulation of vasodilation
regulation of membrane potential
auditory receptor cell differentiation
positive regulation of apoptotic process
response to estrogen
locomotor rhythm
negative regulation of cell volume
saliva secretion
cell maturation
neuromuscular process controlling balance
protein homooligomerization
protein homotetramerization
response to calcium ion
transmembrane transport
micturition
eye blink reflex
smooth muscle contraction involved in micturition
relaxation of vascular smooth muscle
potassium ion transmembrane transport
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