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Invitrogen
DYRK3 Polyclonal Antibody
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DYRK3 Antibody (PA5-103282) in IHC (P)
Immunohistochemistry analysis of DYRK3 in human gastric cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with DYRK3 polyclonal antibody (Product # PA5-103282) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-103282
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human DYRK3(Accession O43781), corresponding to amino acid residues S453-L503.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total DYRK3.
靶标信息
DYRK3 belongs to the DYRK family of dual-specificity protein kinases that catalyze phosphorylation of serine/threonine and tyrosine residues. The members of this family share structural similarity, but differ in their substrate specificity, suggesting their involvement in different cellular functions. DYRK3 is a negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dual specificity tyrosine-phosphorylation-regulated kinase 3; dyrk3; dyrk3 {ECO:0000312|EMBL:AAH97474.1}; KSR; REDK; Regulatory erythroid kinase; RP11-343H5.2; RSU2
基因别名: BC006704; DYRK3
UniProt ID: (Rat) Q4V8A3, (Mouse) Q8BM34
Entrez Gene ID: (Rat) 304775, (Mouse) 226419
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
ATP binding
nucleotide binding
protein binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
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