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Invitrogen
LNK Polyclonal Antibody
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FIGURE: 1 / 3
LNK Antibody (PA5-104134) in ICC/IF
Immunofluorescent analysis of LNK in HepG2 cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and LNK polyclonal antibody (Product # PA5-104134) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-104134
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SH2B3(Accession Q9UQQ2), corresponding to amino acid residues M1-H33.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SH2B3.
Target Information
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: lymphocyte-specific adapter protein Lnk; signal transduction protein Lnk; unnamed protein product
Gene Aliases: IDDM20; LNK
UniProt ID: (Human) Q9UQQ2
Entrez Gene ID: (Human) 10019
neutrophil homeostasis
myeloid cell homeostasis
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
negative regulation of cell proliferation
hemopoiesis
embryonic hemopoiesis
intracellular signal transduction
monocyte homeostasis
megakaryocyte development
cellular response to interleukin-3
thrombopoietin-mediated signaling pathway
negative regulation of MAPK cascade
negative regulation of JAK-STAT cascade
erythrocyte development
negative regulation of protein kinase B signaling
negative regulation of response to cytokine stimulus
myeloid cell development
negative regulation of chemokine-mediated signaling pathway
negative regulation of platelet aggregation
negative regulation of Kit signaling pathway
negative regulation of receptor signaling pathway via STAT
cellular response to chemokine
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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