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Invitrogen
ATP1A3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-104166
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ATP1A3(Accession P13637), corresponding to amino acid residues F90-Q140.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total ATP1A3.
Target Information
The sodium/potassium ATPase is an integral membrane enzyme found in all cells of higher organisms and is responsible for the ATP-dependent transport of sodium and potassium across the cell membrane. This membrane-bound enzyme is related to a number of other ATPases including sarcoplasmic and endoplasmic reticulum calcium ATPase (SERCA) and plasma membrane calcium ATPase (PMCA). The sodium/potassium ATPase consists of a large, multipass, transmembrane catalytic subunit, termed the alpha subunit, and an associated smaller glycoprotein, termed the beta subunit. Studies indicate that there are three isoforms of the alpha subunit (alpha 1, alpha 2, alpha 3) and two isoforms of the beta subunit (beta 1 and beta 2) encoded by two multigene families. The different isoforms of the sodium/potassium ATPase exhibit tissue-specific and developmental patterns of expression. The alpha 1 and beta mRNAs are present in all cell types examined, whereas the alpha 2 and alpha 3 mRNAs exhibit a more restricted pattern of cell-specific expression. The alpha-3 subunit has been found in neuronal and to skeletal and cardiac muscle, lung and stomach tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: (Na+ and K+) ATPase, alpha(III) catalytic subunit; ATPase, Na+/K+ transporting, alpha 3 polypeptide; ATPase, Na+K+ transporting, alpha 3 subunit; EC 3.6.3.9; Na(+)/K(+) ATPase alpha(III) subunit; Na(+)/K(+) ATPase alpha-3 subunit; Na+, K+ activated adenosine triphosphatase alpha subunit; Na+/K+ -ATPase alpha 3 subunit; Na+/K+ ATPase 3; NA,K-ATPase alpha subunit 3; Sodium Potassium ATPase; Sodium pump 3; sodium pump subunit alpha-3; sodium-potassium ATPase catalytic subunit alpha-3; sodium-potassium-ATPase, alpha 3 polypeptide; sodium/potassium-transporting ATPase alpha-3 chain; unnamed protein product
Gene Aliases: AHC2; Atpa-2; Atpa1a3; CAPOS; DEE99; DYT12; RDP
UniProt ID: (Human) P13637, (Mouse) Q6PIC6, (Rat) P06687
Entrez Gene ID: (Human) 478, (Mouse) 232975, (Rat) 24213
potassium ion transport
sodium ion transport
cellular sodium ion homeostasis
response to stress
gamma-aminobutyric acid signaling pathway
learning
memory
circadian rhythm
locomotory behavior
blood circulation
determination of adult lifespan
adult locomotory behavior
visual learning
response to temperature stimulus
response to xenobiotic stimulus
response to hormone
response to lithium ion
establishment or maintenance of transmembrane electrochemical gradient
response to activity
transmission of nerve impulse
calcium-mediated signaling
L-ascorbic acid metabolic process
thalamus development
cerebral cortex development
neurogenesis
cellular potassium ion homeostasis
sleep
brain-derived neurotrophic factor receptor signaling pathway
social behavior
ionotropic glutamate receptor signaling pathway
multicellular organism growth
response to potassium ion
response to immobilization stress
sodium ion export from cell
locomotion
fear response
protein kinase B signaling
pore complex assembly
carboxylic acid transport
habituation
regulation of short-term neuronal synaptic plasticity
neuromuscular process controlling balance
cognition
neuromuscular process
response to electrical stimulus
membrane depolarization
cardiac muscle contraction
motor behavior
ERK1 and ERK2 cascade
response to monoamine
regulation of cardiac muscle cell membrane potential
response to environmental enrichment
walking behavior
inhibitory chemical synaptic transmission
hydrogen ion transmembrane transport
response to methamphetamine hydrochloride
cellular response to beta-amyloid
neuron projection maintenance
potassium ion import across plasma membrane
cellular response to retinoic acid
cellular response to thyroid hormone stimulus
cellular cation homeostasis
regulation of resting membrane potential
cellular response to steroid hormone stimulus
cell communication by electrical coupling involved in cardiac conduction
response to glycoside
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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