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NOD2 Polyclonal Antibody

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NOD2 Polyclonal Antibody

产品信息

PA5-104317

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:200
-

免疫细胞化学 (ICC/IF)

1:100-1:500
-
产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human NOD2(Accession Q9HC29), corresponding to amino acid residues A110-G160.
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2853627

产品详细信息

Antibody detects endogenous levels of total NOD2.

靶标信息

NOD2 is a member of the apoptosis regulating protein family that includes caspase recruitment-domains, as well as Apaf-1 and NOD1. It contains two N-terminal CARDs, a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). NOD2 is expressed in monocytes (whereas NOD1 is expressed in multiple tissues). NOD2 plays a role in regulating NF-kappaB, acts as an intracellular receptor for bacterial lipopolysaccharides, and contributes to inflammatory bowel disease (IBD) and Crohn's disease.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: caspase recruitment domain family, member 15; Caspase recruitment domain-containing protein 15; Inflammatory bowel disease protein 1; NOD 2; NOD-2; NOD2 protein; Nucleotide-binding oligomerization domain-containing protein 2

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基因别名: ACUG; BLAU; CARD15; CD; F830032C23Rik; IBD1; Nlrc2; NOD2

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Entrez Gene ID: (Rat) 291912, (Mouse) 257632

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功能
ATP binding enzyme binding protein kinase binding muramyl dipeptide binding peptidoglycan binding CARD domain binding nucleotide binding protein binding endodeoxyribonuclease activity, producing 5'-phosphomonoesters scaffold/adaptor protein non-motor microtubule binding protein
参与通路
innate immune response in mucosa activation of immune response cytokine production involved in immune response immunoglobulin production involved in immunoglobulin mediated immune response positive regulation of dendritic cell antigen processing and presentation negative regulation of T cell mediated immunity positive regulation of dendritic cell cytokine production positive regulation of type 2 immune response negative regulation of inflammatory response to antigenic stimulus positive regulation of humoral immune response mediated by circulating immunoglobulin positive regulation of antibacterial peptide biosynthetic process positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria response to nutrient positive regulation of cell proliferation detection of bacterium maintenance of gastrointestinal epithelium positive regulation of protein ubiquitination negative regulation of NF-kappaB transcription factor activity response to peptidoglycan response to muramyl dipeptide response to lipopolysaccharide detection of muramyl dipeptide negative regulation of interferon-gamma production negative regulation of interleukin-12 production negative regulation of interleukin-18 production negative regulation of interleukin-2 production negative regulation of tumor necrosis factor production positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-17 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade negative regulation of toll-like receptor 2 signaling pathway activation of MAPK activity involved in innate immune response intracellular signal transduction defense response to bacterium regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA positive regulation of MAPK cascade positive regulation of phosphatidylinositol 3-kinase activity negative regulation of growth of symbiont in host innate immune response positive regulation of innate immune response positive regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade positive regulation of epithelial cell proliferation positive regulation of interleukin-1 beta secretion regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phagocytosis defense response to Gram-positive bacterium positive regulation of B cell activation positive regulation of NF-kappaB transcription factor activity positive regulation of oxidoreductase activity positive regulation of nitric-oxide synthase biosynthetic process positive regulation of prostaglandin-endoperoxide synthase activity positive regulation of ERK1 and ERK2 cascade nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to peptidoglycan cellular response to muramyl dipeptide cellular response to organic cyclic compound macrophage inflammatory protein-1 alpha production regulation of neutrophil chemotaxis negative regulation of macrophage apoptotic process positive regulation of prostaglandin-E synthase activity cytokine secretion involved in immune response immune system process defense response inflammatory response signal transduction detection of biotic stimulus protein oligomerization positive regulation of cytokine production involved in inflammatory response
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