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Invitrogen
D4 Dopamine Receptor Polyclonal Antibody
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D4 Dopamine Receptor Antibody (PA5-104385) in ICC/IF
Immunofluorescent analysis of D4 Dopamine Receptor in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and D4 Dopamine Receptor polyclonal antibody (Product # PA5-104385) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mou... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-104385
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human DRD4(Accession P21917), corresponding to amino acid residues A363-V413.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total DRD4.
靶标信息
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: D(2C) dopamine receptor; D(4) dopamine receptor; Dopamine 4 receptor; Dopamine D4 receptor; dopamine receptor 4; seven transmembrane helix receptor
基因别名: AW125663; D4DR; D4R; D4RA; Drd-4; DRD4
UniProt ID: (Mouse) P51436
Entrez Gene ID: (Human) 1815, (Rat) 25432, (Mouse) 13491
dopamine neurotransmitter receptor activity, coupled via Gi/Go
G-protein coupled receptor activity
adrenergic receptor activity
dopamine neurotransmitter receptor activity
G-protein coupled serotonin receptor activity
protein binding
potassium channel regulator activity
SH3 domain binding
neurotransmitter receptor activity
dopamine binding
identical protein binding
epinephrine binding
norepinephrine binding
drug binding
signal transducer activity
G-protein coupled amine receptor activity
G-protein coupled receptor
behavioral fear response
synaptic transmission, dopaminergic
response to amphetamine
cellular calcium ion homeostasis
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting dopamine receptor signaling pathway
chemical synaptic transmission
adult locomotory behavior
adult behavior
response to histamine
social behavior
locomotory exploration behavior
regulation of dopamine metabolic process
fear response
regulation of circadian rhythm
positive regulation of MAPK cascade
behavioral response to cocaine
behavioral response to ethanol
arachidonic acid secretion
negative regulation of protein secretion
regulation of transport
positive regulation of dopamine uptake involved in synaptic transmission
inhibitory postsynaptic potential
phospholipase C-activating dopamine receptor signaling pathway
adrenergic receptor signaling pathway
G protein-coupled serotonin receptor signaling pathway
regulation of postsynaptic neurotransmitter receptor internalization
activation of MAPK activity
negative regulation of adenylate cyclase activity
dopamine receptor signaling pathway
short-term memory
circadian rhythm
locomotory behavior
associative learning
olfactory learning
photoperiodism
negative regulation of cAMP biosynthetic process
positive regulation of sodium:proton antiporter activity
positive regulation of kinase activity
regulation of neurotransmitter secretion
response to steroid hormone
modulation of synaptic transmission
regulation of calcium-mediated signaling
retina development in camera-type eye
positive regulation of penile erection
negative regulation of voltage-gated calcium channel activity
positive regulation of excitatory postsynaptic potential
signal transduction
sensory perception of chemical stimulus
rhythmic process
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