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Phospho-CaMKII alpha/beta/delta (Tyr231) Polyclonal Antibody

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Phospho-CaMKII alpha/beta/delta (Tyr231) Polyclonal Antibody

产品信息

PA5-104580

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human CAMK2B(Accession Q13554), corresponding to amino acid residues around phosphorylated Tyr231.
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

sequential chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2816055

产品详细信息

Antibody detects endogenous levels of CaMKII only when phosphorylated at Tyr231.

靶标信息

The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes, designated alpha, beta, gamma and delta, which may or may not be co-expressed in the same tissue type. CaMKII alpha is autophosphorylated on Thr 286 upon the binding of the Ca2+/CaM complex to the autoinhibitory domain of CaMKII. This process is called Ca2+/CaM trapping, which is thought to be involved in the synaptic encoding of information.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: alpha CaM kinase II; alpha-CaMKII; Ca++/calmodulin-dependent protein kinase 2 delta subunit; Ca++/calmodulin-dependent protein kinase II beta subunit; Ca++/calmodulin-dependent protein kinase II delta subunit; Ca++/calmodulin-dependent protein kinase II, delta subunit; Ca2+/calmodulin-dependent protein kinase II alpha; Calci; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta; calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; calcium/calmodulin-dependent protein kinase II alpha subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase type II beta chain; calcium/calmodulin-dependent protein kinase type II delta chain; Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase type II subunit beta; Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II subunit alpha; CaM kinase II subunit beta; CaM kinase II subunit delta; caM-kinase II alpha chain; caM-kinase II beta chain; caM-kinase II delta chain; CAMK; CaMK II; CaMK-2 delta; CaMK-2a; CAMK-II; caMK-II subunit alpha; caMK-II subunit beta; caMK-II subunit delta; CaMK2 delta; CaMK2- delta; CaMK2-a; CAMK2G; CAMKG

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基因别名: 2810011D23Rik; 8030469K03Rik; [d]-CaMKII; CAM2; CaMK II; CAMK1; CAMK2; CAMK2A; CAMK2B; CAMK2D; CAMKA; CAMKB; CAMKD; Camki; CaMKII; Ck2b; KIAA0968; Kiaa4163; mKIAA0968; PK2CDD; PKCCD; R74975; RATCAMKI

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UniProt ID: (Mouse) P11798, (Rat) P11275, (Rat) P08413, (Mouse) P28652, (Rat) P15791, (Mouse) Q6PHZ2

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Entrez Gene ID: (Mouse) 12322, (Rat) 25400, (Rat) 24245, (Mouse) 12323, (Rat) 24246, (Mouse) 108058

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功能
nucleotide binding protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity protein binding calmodulin binding ATP binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups GTPase activating protein binding glutamate receptor binding protein homodimerization activity phospholipase binding sodium channel inhibitor activity titin binding ion channel binding nitric-oxide synthase binding non-receptor serine/threonine protein kinase
参与通路
G1/S transition of mitotic cell cycle response to ischemia protein phosphorylation calcium ion transport positive regulation of cardiac muscle cell apoptotic process phosphorylation peptidyl-serine phosphorylation ionotropic glutamate receptor signaling pathway angiotensin-activated signaling pathway protein autophosphorylation regulation of neurotransmitter secretion regulation of neuronal synaptic plasticity positive regulation of NF-kappaB transcription factor activity positive regulation of calcium ion transport regulation of mitochondrial membrane permeability involved in apoptotic process inhibitory G-protein coupled receptor phosphorylation positive regulation of neuron projection development regulation of synaptic transmission, cholinergic positive regulation of phospholipase A2 activity response to cadmium ion regulation of long-term neuronal synaptic plasticity cell projection morphogenesis neuromuscular process controlling balance long-term synaptic potentiation activation of meiosis involved in egg activation positive regulation of dendritic spine morphogenesis positive regulation of synapse maturation positive regulation of apoptotic signaling pathway nervous system development cell differentiation response to hypoxia regulation of sodium ion transport regulation of membrane depolarization regulation of G2/M transition of mitotic cell cycle positive regulation of cardiac muscle hypertrophy regulation of cell communication by electrical coupling regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion positive regulation of smooth muscle cell migration peptidyl-threonine phosphorylation cellular potassium ion homeostasis endoplasmic reticulum calcium ion homeostasis positive regulation of Rac protein signal transduction positive regulation of smooth muscle cell proliferation protein oligomerization relaxation of cardiac muscle cardiac muscle contraction regulation of cellular localization cell growth involved in cardiac muscle cell development positive regulation of ERK1 and ERK2 cascade cardiac muscle cell contraction regulation of cardiac muscle cell action potential regulation of cardiac muscle cell action potential involved in regulation of contraction regulation of cell communication by electrical coupling involved in cardiac conduction regulation of relaxation of cardiac muscle negative regulation of sodium ion transmembrane transport regulation of calcium ion transmembrane transport via high voltage-gated calcium channel negative regulation of sodium ion transmembrane transporter activity
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