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Invitrogen
Phospho-Bcr (Tyr360) Polyclonal Antibody
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Phospho-Bcr (Tyr360) Antibody (PA5-104787) in ICC/IF
Immunofluorescent analysis of Phospho-Bcr (Tyr360) in HeLa cells(4h of LPS treatment). Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Phospho-Bcr (Tyr360) polyclonal antibody (Product # PA5-104787) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (r... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-104787
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human BCR(Accession P11274), corresponding to amino acid residues around phosphorylated Tyr360.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of Bcr only when phosphorylated at Tyrosine 360.
靶标信息
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ABL; BCR protein; bcr/abl; breakpoint cluster region homolog; Breakpoint cluster region protein; c-ABL; c-abl oncogene 1; EC 2.7.11.1; JTK7; p150; Renal carcinoma antigen NY-REN-26; RP11-83J21.1; v-abl
基因别名: 5133400C09Rik; AI561783; AI853148; BCR; BCR1; D22S11; Kiaa3017; mKIAA3017
UniProt ID: (Rat) F1LXF1, (Mouse) Q6PAJ1
Entrez Gene ID: (Rat) 309696, (Mouse) 110279
brain development
actin cytoskeleton organization
negative regulation of cell migration
response to lipopolysaccharide
intracellular signal transduction
inner ear morphogenesis
negative regulation of neutrophil degranulation
positive regulation of GTPase activity
protein autophosphorylation
platelet-derived growth factor receptor signaling pathway
negative regulation of inflammatory response
positive regulation of phagocytosis
neuromuscular process controlling balance
regulation of cell cycle
protein phosphorylation
signal transduction
phosphorylation
regulation of Rho protein signal transduction
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