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Invitrogen
Phospho-mTOR (Thr2446) Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-104899
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MTOR(Accession P42345), corresponding to amino acid residues around phosphorylated Thr2446.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of mTOR only when phosphorylated at Threonine 2446.
Target Information
FRAP1 (mTOR) is a serine/threonine kinase that plays a critical role in cellular growth and proliferation. Perturbations in the mTOR/PI3-kinase/AKT pathway are associated with numerous forms of cancer. FRAP1 is also the target of rapamycin and its analogues, which are currently used as immunosuppressants and cancer therapeutics. Mutations affecting the gene results in Smith-Kingsmore syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: angiopoietin-like factor CDT6; FK506 binding protein 12-rapamycin associated protein 1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP-rapamycin associated protein (FRAP); FKBP-rapamycin-associated protein FRAP; FKBP12-rapamycin complex-associated protein; m-TOR; Mammalian target of rapamycin; Mechanistic target of rapamycin; mTOR; mTORC1; Rapamycin and FKBP12 target 1; rapamycin and FKBP12 target-1 protein; Rapamycin target protein 1; RAPT1; Serine/threonine-protein kinase mTOR; Tyrosine-protein kinase mTOR
Gene Aliases: 2610315D21Rik; AI327068; flat; FRAP; FRAP1; FRAP2; MTOR; RAFT1; RAPT1
UniProt ID: (Mouse) Q9JLN9, (Rat) P42346
Entrez Gene ID: (Mouse) 56717, (Rat) 56718
nucleotide binding
RNA polymerase III type 1 promoter DNA binding
RNA polymerase III type 2 promoter DNA binding
RNA polymerase III type 3 promoter DNA binding
TFIIIC-class transcription factor binding
protein serine/threonine kinase activity
protein binding
ATP binding
drug binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
phosphotransferase activity, alcohol group as acceptor
protein domain specific binding
ribosome binding
protein dimerization activity
phosphoprotein binding
non-receptor serine/threonine protein kinase
protein modifying enzyme
double-strand break repair via homologous recombination
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
regulation of glycogen biosynthetic process
regulation of carbohydrate metabolic process
protein phosphorylation
response to stress
germ cell development
negative regulation of autophagy
positive regulation of lamellipodium assembly
positive regulation of gene expression
positive regulation of myotube differentiation
cell growth
negative regulation of macroautophagy
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
cell projection organization
positive regulation of actin filament polymerization
ruffle organization
regulation of myelination
cellular response to nutrient levels
TOR signaling
regulation of fatty acid beta-oxidation
regulation of response to food
response to insulin
regulation of actin cytoskeleton organization
regulation of GTPase activity
response to amino acid
regulation of carbohydrate utilization
regulation of osteoclast differentiation
positive regulation of translation
negative regulation of cell size
regulation of protein kinase activity
positive regulation of transcription from RNA polymerase III promoter
protein autophosphorylation
positive regulation of lipid biosynthetic process
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of stress fiber assembly
negative regulation of NFAT protein import into nucleus
positive regulation of protein kinase B signaling
cellular response to hypoxia
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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