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Invitrogen
Phospho-P2X7 (Ser390) Polyclonal Antibody
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Phospho-P2X7 (Ser390) Antibody (PA5-105077) in WB
Western blot analysis of Phospho-P2X7 (Ser390) in Jurkat cell lysate (Lane 1: treated with phospho-blocking peptide; Lane 2: treated with non-phospho-blocking peptide). Samples were incubated with Phospho-P2X7 (Ser390) polyclonal antibody (Product # PA5-105077).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-105077
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human P2RX7(Accession Q99572), corresponding to amino acid residues around phosphorylated Ser390.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of P2X7 only when phosphorylated at Ser390.
靶标信息
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay criteria.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP receptor; MGC20089; P2X purinoceptor 7; p2X receptor 7; P2X7; P2X7 purinoceptor; P2X7 receptor; P2Z; P2Z receptor; Purinergic receptor; purinergic receptor P2X7
基因别名: AI467586; P2RX7; P2X(7); P2x7; P2X7R
UniProt ID: (Rat) Q64663, (Mouse) Q9Z1M0
Entrez Gene ID: (Rat) 29665, (Mouse) 18439
magnesium ion binding
lipopolysaccharide binding
purinergic nucleotide receptor activity
receptor activity
extracellular ATP-gated cation channel activity
receptor binding
copper ion binding
protein binding
ATP binding
zinc ion binding
channel activity
protein serine/threonine kinase activator activity
scaffold protein binding
ion channel activity
ligand-gated ion channel
activation of MAPK activity
cell morphogenesis
phagolysosome assembly
positive regulation of T cell mediated cytotoxicity
positive regulation of protein phosphorylation
regulation of sodium ion transport
protein phosphorylation
membrane protein ectodomain proteolysis
phospholipid transfer to membrane
cation transport
calcium ion transport
cell volume homeostasis
membrane budding
inflammatory response
mitochondrion organization
plasma membrane organization
cell surface receptor signaling pathway
response to mechanical stimulus
response to bacterium
response to organic substance
response to zinc ion
gene expression
positive regulation of calcium ion transport into cytosol
programmed cell death
positive regulation of glutamate secretion
positive regulation of gamma-aminobutyric acid secretion
response to organic cyclic compound
organic cation transport
synaptic vesicle exocytosis
protein processing
neuronal action potential
sensory perception of pain
cytolysis
positive regulation of bone mineralization
cellular response to extracellular stimulus
bleb assembly
positive regulation of prostaglandin secretion
response to lipopolysaccharide
positive regulation of interleukin-1 beta production
positive regulation of interleukin-6 production
collagen metabolic process
response to ATP
response to fluid shear stress
purinergic nucleotide receptor signaling pathway
T cell proliferation
response to drug
T cell homeostasis
positive regulation of apoptotic process
positive regulation of catalytic activity
NAD transport
negative regulation of MAPK cascade
positive regulation of MAPK cascade
multicellular organismal protein catabolic process
phospholipid translocation
positive regulation of ossification
negative regulation of bone resorption
positive regulation of cytolysis
ceramide biosynthetic process
pore complex assembly
skeletal system morphogenesis
homeostasis of number of cells within a tissue
positive regulation of protein secretion
positive regulation of cytokine secretion
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
defense response to Gram-positive bacterium
release of sequestered calcium ion into cytosol
protein oligomerization
positive regulation of cytoskeleton organization
response to calcium ion
response to electrical stimulus
membrane depolarization
positive regulation of mitochondrial depolarization
positive regulation of lymphocyte apoptotic process
cellular response to organic cyclic compound
reactive oxygen species metabolic process
apoptotic signaling pathway
extrinsic apoptotic signaling pathway
cation transmembrane transport
transport
ion transport
positive regulation of gene expression
phospholipid scrambling
positive regulation of ion transmembrane transport
negative regulation of cell volume
positive regulation of glycolytic process
cellular response to dsRNA
positive regulation of bleb assembly
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