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Invitrogen

Phospho-P2X7 (Ser390) Polyclonal Antibody

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Phospho-P2X7 (Ser390) Polyclonal Antibody

Product Details

PA5-105077

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human P2RX7(Accession Q99572), corresponding to amino acid residues around phosphorylated Ser390.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816550

Product Specific Information

Antibody detects endogenous levels of P2X7 only when phosphorylated at Ser390.

Target Information

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay criteria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATP agonist non-selective cationic pore-forming protein; ATP receptor; ATP-gated ion channel; splice variant; P2X7(k); ligand gated ion channel; MGC20089; P2X purinoceptor 7; P2X purinoceptor 7-like; p2X receptor 7; P2X7; P2X7 purinoceptor; P2X7 receptor; P2X7; cervical cancer susceptibility protein; P2Z; P2Z receptor; purinergic receptor P2X, ligand gated ion channel, 7; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7; purnergic receptor P2X 7; unnamed protein product

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Gene Aliases: P2X(7); P2X7; P2X7R

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UniProt ID: (Human) Q99572, (Mouse) Q9Z1M0, (Rat) Q64663

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Entrez Gene ID: (Human) 5027, (Mouse) 18439, (Rat) 29665

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Function(s)
lipopolysaccharide binding purinergic nucleotide receptor activity extracellular ATP-gated cation channel activity receptor binding ion channel activity potassium channel activity sodium channel activity protein binding ATP binding channel activity signaling receptor activity identical protein binding magnesium ion binding copper ion binding zinc ion binding protein serine/threonine kinase activator activity scaffold protein binding
Process(es)
regulation of sodium ion transport response to ischemia ion transport cell surface receptor signaling pathway positive regulation of calcium ion transport into cytosol positive regulation of gene expression organophosphate ester transport phospholipid scrambling sensory perception of pain calcium-mediated signaling positive regulation of bone mineralization bleb assembly positive regulation of interleukin-1 beta production response to ATP positive regulation of ion transmembrane transport purinergic nucleotide receptor signaling pathway sodium ion transmembrane transport negative regulation of MAPK cascade negative regulation of bone resorption negative regulation of cell volume positive regulation of glycolytic process pore complex assembly regulation of transport positive regulation of cellular component organization positive regulation of cytoskeleton organization membrane depolarization excitatory postsynaptic potential protein homotrimerization calcium ion transmembrane transport cellular response to ATP potassium ion transmembrane transport apoptotic signaling pathway extrinsic apoptotic signaling pathway cation transmembrane transport positive regulation of NLRP3 inflammasome complex assembly positive regulation of bleb assembly cell morphogenesis positive regulation of cytokine production phagolysosome assembly positive regulation of T cell mediated cytotoxicity positive regulation of protein phosphorylation protein phosphorylation membrane protein ectodomain proteolysis phospholipid transfer to membrane cation transport calcium ion transport cell volume homeostasis membrane budding inflammatory response mitochondrion organization plasma membrane organization response to xenobiotic stimulus response to mechanical stimulus response to bacterium response to zinc ion gene expression programmed cell death positive regulation of glutamate secretion positive regulation of gamma-aminobutyric acid secretion synaptic vesicle exocytosis protein processing neuronal action potential protein catabolic process positive regulation of prostaglandin secretion response to lipopolysaccharide positive regulation of interleukin-1 alpha production positive regulation of interleukin-6 production collagen metabolic process response to fluid shear stress T cell proliferation T cell homeostasis positive regulation of apoptotic process positive regulation of catalytic activity NAD transport positive regulation of MAP kinase activity positive regulation of MAPK cascade phospholipid translocation positive regulation of ossification ceramide biosynthetic process skeletal system morphogenesis homeostasis of number of cells within a tissue positive regulation of protein secretion defense response to Gram-positive bacterium release of sequestered calcium ion into cytosol adenine nucleotide transport response to calcium ion response to electrical stimulus positive regulation of mitochondrial depolarization positive regulation of lymphocyte apoptotic process cellular response to dsRNA reactive oxygen species metabolic process regulation of presynaptic dense core granule exocytosis regulation of secretion by cell ATP export
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