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          • Primary Antibodies ›
          • P2X7 Antibodies

          Invitrogen

          Phospho-P2X7 (Ser390) Polyclonal Antibody

          View all (22) P2X7 antibodies

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          Cite Phospho-P2X7 (Ser390) Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (1)
          Phospho-P2X7 (Ser390) Antibody in Western Blot (WB)
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          Phospho-P2X7 (Ser390) Antibody in Western Blot (WB)
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          Phospho-P2X7 (Ser390) Antibody (PA5-105077) in WB

          Western blot analysis of Phospho-P2X7 (Ser390) in Jurkat cell lysate (Lane 1: treated with phospho-blocking peptide; Lane 2: treated with non-phospho-blocking peptide). Samples were incubated with Phospho-P2X7 (Ser390) polyclonal antibody (Product # PA5-105077). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Phospho-P2X7 (Ser390) Antibody in Western Blot (WB)
          Phospho-P2X7 (Ser390) Polyclonal Antibody

          Product Details

          PA5-105077

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          A synthesized peptide derived from human P2RX7(Accession Q99572), corresponding to amino acid residues around phosphorylated Ser390.
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          100 µg

          Purification

          sequential chromatography

          Storage buffer

          PBS, pH 7.4, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2816550

          Product Specific Information

          Antibody detects endogenous levels of P2X7 only when phosphorylated at Ser390.

          Target Information

          The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay criteria.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: ATP agonist non-selective cationic pore-forming protein; ATP receptor; ligand gated ion channel; MGC20089; P2X purinoceptor 7; p2X receptor 7; P2X7; P2X7 purinoceptor; P2X7 receptor; P2X7; cervical cancer susceptibility protein; P2Z; P2Z receptor; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 7; purinergic receptor P2X7; purnergic receptor P2X 7; unnamed protein product

          View more View less

          Gene Aliases: AI467586; P2RX7; P2X(7); P2X7; P2X7R

          View more View less

          UniProt ID: (Human) Q99572, (Rat) Q64663, (Mouse) Q9Z1M0

          View more View less

          Entrez Gene ID: (Human) 5027, (Rat) 29665, (Mouse) 18439

          View more View less

          Function(s)
          nucleotide binding lipopolysaccharide binding purinergic nucleotide receptor activity extracellular ATP-gated cation channel activity receptor binding ion channel activity potassium channel activity sodium channel activity protein binding ATP binding GTP binding channel activity signaling receptor activity identical protein binding metal ion binding magnesium ion binding receptor activity copper ion binding zinc ion binding protein serine/threonine kinase activator activity scaffold protein binding ligand-gated ion channel
          Process(es)
          MAPK cascade cell morphogenesis phagolysosome assembly T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity regulation of sodium ion transport response to ischemia membrane protein ectodomain proteolysis phospholipid transfer to membrane ion transport cation transport calcium ion transport cell volume homeostasis membrane budding inflammatory response mitochondrion organization plasma membrane organization cell surface receptor signaling pathway protein secretion response to xenobiotic stimulus response to mechanical stimulus response to bacterium response to zinc ion gene expression positive regulation of calcium ion transport into cytosol positive regulation of gene expression programmed cell death glutamate secretion positive regulation of glutamate secretion gamma-aminobutyric acid secretion positive regulation of gamma-aminobutyric acid secretion organophosphate ester transport synaptic vesicle exocytosis protein processing phospholipid scrambling sensory perception of pain calcium-mediated signaling protein catabolic process positive regulation of bone mineralization bleb assembly positive regulation of prostaglandin secretion prostaglandin secretion response to lipopolysaccharide positive regulation of interleukin-1 alpha production positive regulation of interleukin-1 beta production positive regulation of interleukin-6 production collagen metabolic process response to ATP ion transmembrane transport response to fluid shear stress positive regulation of ion transmembrane transport purinergic nucleotide receptor signaling pathway sodium ion transmembrane transport T cell proliferation T cell homeostasis positive regulation of apoptotic process NAD transport negative regulation of MAPK cascade positive regulation of MAPK cascade phospholipid translocation positive regulation of ossification negative regulation of bone resorption negative regulation of cell volume positive regulation of glycolytic process ceramide biosynthetic process pore complex assembly skeletal system morphogenesis homeostasis of number of cells within a tissue positive regulation of protein secretion defense response to Gram-positive bacterium regulation of transport positive regulation of cellular component organization release of sequestered calcium ion into cytosol positive regulation of cytoskeleton organization response to calcium ion response to electrical stimulus establishment of localization in cell mitochondrial depolarization membrane depolarization positive regulation of mitochondrial depolarization excitatory postsynaptic potential positive regulation of macrophage cytokine production protein homotrimerization lymphocyte apoptotic process positive regulation of lymphocyte apoptotic process T cell apoptotic process positive regulation of T cell apoptotic process calcium ion transmembrane transport cellular response to ATP cellular response to dsRNA potassium ion transmembrane transport reactive oxygen species metabolic process apoptotic signaling pathway extrinsic apoptotic signaling pathway cation transmembrane transport positive regulation of NLRP3 inflammasome complex assembly positive regulation of bleb assembly activation of MAPK activity positive regulation of protein phosphorylation protein phosphorylation response to organic substance response to organic cyclic compound organic cation transport neuronal action potential cytolysis cellular response to extracellular stimulus response to drug positive regulation of catalytic activity multicellular organismal protein catabolic process positive regulation of cytolysis positive regulation of cytokine secretion positive regulation of interleukin-1 alpha secretion positive regulation of interleukin-1 beta secretion protein oligomerization cellular response to organic cyclic compound transport
          It has to be done as per old AB suggested Products section.

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