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Invitrogen
Phospho-TrkA/TrkB (Tyr785, Tyr816) Polyclonal Antibody
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Phospho-TrkA/TrkB (Tyr785, Tyr816) Antibody (PA5-105133) in ICC/IF
Immunocytochemistry analysis of Phospho-TrkA/TrkB (Tyr785, Tyr816) in Hela cells (4h of LPS treatment). The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Phospho-TrkA/TrkB (Tyr785, Tyr816) polyclonal antibody (Product # PA5-105133) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conj... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-105133
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NTRK1(Accession P04629), corresponding to amino acid residues around phosphorylated Tyr785.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of TrkA /TrkB only when phosphorylated at Tyr785.
靶标信息
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BDNF/NT-3 growth factors receptor; gp140trk; GP145-TrkB; GP145-TrkB/GP95-TrkB; High affinity nerve growth factor receptor; neural receptor protein-tyrosine kinase (trkB); Neurotrophic tyrosine kinase receptor type 1; Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine receptor kinase type 2; p140-TrkA; Slow nerve growth factor receptor; trk; Trk-A; Trk-B; TRK1-transforming tyrosine kinase protein; TrkA neurotrophin receptor; trkA proto-oncogene receptor; TrkB tyrosine kinase; Tropomyosin-related kinase A; Tropomyosin-related kinase B; Tyrosine kinase receptor; Tyrosine kinase receptor A
基因别名: C80751; GP145-TrkB/GP95-TrkB; MTC; NTRK1; NTRK2; RATTRKB1; Tkr; Tkrb; TRK; trk-B; TRKA; TRKB; TRKB1
UniProt ID: (Mouse) Q3UFB7, (Rat) P35739, (Mouse) P15209, (Rat) Q63604
Entrez Gene ID: (Mouse) 18211, (Rat) 59109, (Mouse) 18212, (Rat) 25054
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
neurotrophin receptor activity
neurotrophin p75 receptor binding
protein binding
ATP binding
nerve growth factor receptor activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase binding
protein homodimerization activity
ephrin receptor binding
nerve growth factor binding
neurotrophin binding
brain-derived neurotrophic factor binding
brain-derived neurotrophic factor-activated receptor activity
transmembrane signal receptor
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
multicellular organism development
nervous system development
axon guidance
learning or memory
programmed cell death involved in cell development
response to activity
phosphorylation
peptidyl-tyrosine phosphorylation
sensory perception of pain
cell differentiation
B cell differentiation
response to nutrient levels
response to nicotine
nerve growth factor signaling pathway
mechanoreceptor differentiation
response to drug
positive regulation of programmed cell death
negative regulation of neuron apoptotic process
positive regulation of angiogenesis
protein autophosphorylation
neurotrophin TRK receptor signaling pathway
sympathetic nervous system development
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
positive regulation of NF-kappaB transcription factor activity
response to electrical stimulus
positive regulation of synapse assembly
positive regulation of synaptic transmission, glutamatergic
Sertoli cell development
innervation
axonogenesis involved in innervation
behavioral response to formalin induced pain
cellular response to nicotine
cellular response to growth factor stimulus
negative regulation of neuron death
cellular response to nerve growth factor stimulus
aging
circadian rhythm
negative regulation of cell proliferation
response to radiation
positive regulation of neuron projection development
olfactory nerve development
response to ethanol
positive regulation of Ras protein signal transduction
response to axon injury
response to hydrostatic pressure
positive regulation of ERK1 and ERK2 cascade
vasculogenesis
neuron migration
neuromuscular junction development
learning
long-term memory
feeding behavior
positive regulation of cell proliferation
positive regulation of gene expression
glutamate secretion
positive regulation of phosphatidylinositol 3-kinase signaling
regulation of metabolic process
central nervous system neuron development
cerebral cortex development
neuron differentiation
brain-derived neurotrophic factor receptor signaling pathway
positive regulation of peptidyl-serine phosphorylation
calcium-mediated signaling using intracellular calcium source
neurotrophin signaling pathway
regulation of GTPase activity
regulation of MAPK cascade
positive regulation of MAPK cascade
retinal rod cell development
regulation of neurotransmitter secretion
oligodendrocyte differentiation
peripheral nervous system neuron development
positive regulation of axonogenesis
regulation of dendrite development
regulation of protein kinase B signaling
retina development in camera-type eye
long-term synaptic potentiation
cellular response to amino acid stimulus
positive regulation of glucocorticoid receptor signaling pathway
negative regulation of anoikis
inflammatory response
response to light stimulus
response to auditory stimulus
cellular response to tumor necrosis factor
cellular response to brain-derived neurotrophic factor stimulus
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