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Invitrogen

Phospho-HES1 (Ser37) Polyclonal Antibody

View all (17) HES1 antibodies

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Phospho-HES1 (Ser37) Polyclonal Antibody

Product Details

PA5-105350

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human HES1(Accession Q14469), corresponding to amino acid residues around phosphorylated Ser37.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816778

Product Specific Information

Antibody detects endogenous levels of HES1 only when phosphorylated at Ser37.

Target Information

This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: class B basic helix-loop-helix protein 39; FLJ20408; hairy; hairy and enhancer of split 1; hairy homolog; Hairy-like; hairy-like protein; HES1; RHL; unnamed protein product

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Gene Aliases: bHLHb39; HES-1; HHL; HRY

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UniProt ID: (Human) Q14469, (Rat) Q04666, (Mouse) P35428

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Entrez Gene ID: (Human) 3280, (Rat) 29577, (Mouse) 15205

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Function(s)
RNA polymerase II transcription factor activity, sequence-specific DNA binding bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding transcription corepressor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding protein binding JUN kinase binding identical protein binding protein homodimerization activity histone deacetylase binding HLH domain binding sequence-specific DNA binding macromolecular complex binding protein dimerization activity chaperone binding RNA polymerase II sequence-specific DNA binding transcription factor binding E-box binding N-box binding sequence-specific double-stranded DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development liver development embryonic heart tube morphogenesis outflow tract morphogenesis regulation of secondary heart field cardioblast proliferation ventricular septum development regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell adhesion Notch signaling pathway smoothened signaling pathway pattern specification process positive regulation of cell proliferation response to virus anterior/posterior pattern specification positive regulation of gene expression negative regulation of gene expression negative regulation of neuron projection development cell migration telencephalon development midbrain-hindbrain boundary morphogenesis oculomotor nerve development trochlear nerve development hindbrain morphogenesis forebrain radial glial cell differentiation neural tube development pituitary gland development adenohypophysis development neuron differentiation lung development positive regulation of BMP signaling pathway midbrain development pancreas development somatic stem cell population maintenance hair cell differentiation aorta morphogenesis ascending aorta morphogenesis positive regulation of T cell proliferation positive regulation of tyrosine phosphorylation of STAT protein regulation of protein complex assembly response to alkaloid positive regulation of DNA binding cell fate commitment negative regulation of cell differentiation regulation of fat cell differentiation negative regulation of auditory receptor cell differentiation negative regulation of neuron differentiation positive regulation of glial cell differentiation positive regulation of Notch signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of mitotic cell cycle, embryonic lateral inhibition regulation of JAK-STAT cascade positive regulation of JAK-STAT cascade cell maturation regulation of timing of cell differentiation thymus development cell morphogenesis involved in neuron differentiation positive regulation of astrocyte differentiation negative regulation of oligodendrocyte differentiation artery morphogenesis regulation of epithelial cell proliferation regulation of neurogenesis negative regulation of neurogenesis inner ear receptor stereocilium organization regulation of timing of neuron differentiation negative regulation of glial cell proliferation ventricular septum morphogenesis ureteric bud morphogenesis labyrinthine layer blood vessel development common bile duct development negative regulation of stomach neuroendocrine cell differentiation cardiac neural crest cell development involved in outflow tract morphogenesis pharyngeal arch artery morphogenesis protein-containing complex assembly cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to fatty acid glomerulus vasculature development comma-shaped body morphogenesis S-shaped body morphogenesis renal interstitial fibroblast development metanephric nephron tubule morphogenesis cochlea development establishment of epithelial cell polarity negative regulation of calcium ion import response to thyroid hormone vascular smooth muscle cell development neuronal stem cell population maintenance response to Aroclor 1254 negative regulation of cell fate determination cellular response to nerve growth factor stimulus negative regulation of pancreatic A cell differentiation negative regulation of stem cell differentiation negative regulation of pro-B cell differentiation negative regulation of forebrain neuron differentiation negative regulation of inner ear receptor cell differentiation nervous system development
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